The analgesic efficacy of etoricoxib compared with oxycodone/acetaminophen in an acute postoperative pain model: a randomized, double-blind clinical trial.

Anesthesia and Analgesia
David J ChangGregory P Geba

Abstract

Our objective in this study was to compare the analgesic effects of etoricoxib and oxycodone/acetaminophen in a postoperative dental pain model. Patients experiencing moderate to severe pain after extraction of two or more third molars were randomized to single doses of etoricoxib 120 mg (n = 100), oxycodone/acetaminophen 10/650 mg (n = 100), or placebo (n = 25). The primary end-point was total pain relief over 6 h. Other end-points included patient global assessment of response to therapy; onset, peak, and duration of effect; and rescue opioid analgesic use. Active treatments were statistically significantly superior to placebo for all efficacy measures. Total pain relief over 6 h for etoricoxib was significantly more than for oxycodone/acetaminophen (P < 0.001). Patient global assessment of response to therapy at 6 and 24 h was superior for etoricoxib. Both drugs achieved rapid onset, although the time was faster for oxycodone/acetaminophen by 5 min. The peak effect was similar for both drugs. Compared with oxycodone/acetaminophen patients, etoricoxib patients experienced a longer analgesic duration, had a smaller percentage requiring rescue opioids during 6 and 24 h, and required less rescue analgesia during 6 and 24 h. Oxyc...Continue Reading

References

Dec 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·S A CooperJ Engel
Jan 20, 1994·Nature·J Vane
May 30, 2002·BMC Family Practice·Eduardo CollantesUNKNOWN Etoricoxib Rheumatoid Arthritis Study Group
Jun 22, 2002·BMJ : British Medical Journal·H Ralph SchumacherJavier Molina
Sep 5, 2002·Rheumatology·K GottesdienerUNKNOWN Protocol 007 Study Group
Jan 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·A David RodriguesNancy G B Agrawal
Mar 5, 2003·Journal of Pain and Symptom Management·Gary M OderdaMatthew Samore

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Citations

Nov 14, 2007·European Journal of Clinical Pharmacology·Shaojun Shi, Ulrich Klotz
Jan 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Grigori SmirnovHannu Kokki
Nov 30, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eustachio NettisAlfredo Tursi
Mar 17, 2009·Journal of Public Health·E Chilet-RosellJ F Horga
Dec 29, 2010·The Clinical Journal of Pain·Stephen E DanielsPaul M Peloso
Oct 31, 2014·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Mudit GuptaChanila S Ramachandra
Jul 28, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paul J DesjardinsAndrew M Tershakovec
Jan 20, 2007·Nihon rinsho. Japanese journal of clinical medicine·Kinomi Yomiya
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 22, 2015·The Journal of Pain : Official Journal of the American Pain Society·Neil SinglaRobert H Dworkin
Jun 17, 2014·The British Journal of Oral & Maxillofacial Surgery·Mario Alberto Isiordia-EspinozaOthoniel Hugo Aragon-Martinez
Apr 14, 2005·The Annals of Pharmacotherapy·Shaunta' D MartinaToni L Ripley
May 9, 2014·The Cochrane Database of Systematic Reviews·Rachel ClarkeR Andrew Moore
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Helen GaskellHenry J McQuay
Sep 12, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K A MakhinovE V Parkhomenko

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