The analysis of antipsychotic drugs in human matrices using LC-MS(/MS)

Drug Testing and Analysis
Eva SaarOlaf H Drummer

Abstract

Antipsychotic drugs (APs) are prescribed for a wide range of psychotic illnesses. With more than 35 APs currently available worldwide, this drug class has rapidly gained importance in both clinical and forensic settings. On account of their chemical properties, many APs are present in human specimens at very low concentrations, which complicate their detection using standard gas chromatography-mass spectrometry (GC-MS) procedures that often cannot provide the required sensitivity. Recent advances in liquid chromatography-(tandem) mass spectrometry LC-MS(/MS) technology have enabled accurate detection and quantification of these compounds in various human specimens, indicated by the increasing number of published methods. Method validation has been a particular focus of analytical chemistry in recent times. Recommendations set by several guidance documents are now widely accepted by the toxicology community, as reflected by the guidelines drafted by leading toxicological societies. This review provides a critical review of single-stage and tandem LC-MS procedures for the detection and quantification of APs, with a particular emphasis on appropriate method validation. The quality of published methods is inconsistent throughout th...Continue Reading

References

Oct 1, 1991·European Journal of Drug Metabolism and Pharmacokinetics·V P ShahR D McDowall
Jan 5, 1995·Forensic Science International : Synergy·W L Wang, E J Cone
Dec 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·D Dadgar, P E Burnett
Oct 12, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M J BoguszF Tuchtenhagen
Sep 9, 2000·Forensic Science International : Synergy·C MüllerW Weinmann
Nov 10, 2000·Journal of the American Society for Mass Spectrometry·R KingT Olah
Apr 17, 2001·Pharmaceutical Research·V P ShahA Yacobi
Dec 1, 2001·Forensic Science International : Synergy·M KollroserC Schober
Feb 28, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M BernaS Glass
Jul 20, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tetsuya ArinobuHiroshi Seno
Dec 17, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·B M M RemmerieN C van de Merbel
Jun 21, 2003·Clinical Chemistry·Thomas M Annesley
Nov 5, 2003·Journal of the American Society for Mass Spectrometry·Riet DamsConstance M Murphy
Mar 17, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhiling ZhouHuande Li
Sep 1, 2004·Journal of Pharmaceutical and Biomedical Analysis·C ChinH T Karnes
Sep 29, 2004·Forensic Science International : Synergy·UNKNOWN Society of Hair Testing
Sep 29, 2004·Forensic Science International : Synergy·Thomas CairnsWilliam Thistle
Sep 29, 2004·Forensic Science International : Synergy·Thomas CairnsWilliam Thistle
Sep 29, 2004·Forensic Science International : Synergy·Thomas CairnsWilliam Thistle
Jun 10, 2005·Forensic Science International : Synergy·Johan K M Aps, Luc C Martens
Jul 12, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Masanori KuboTakahiko Osumi

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Citations

Apr 11, 2013·Forensic Science International : Synergy·Danielle S FisherRobert J Flanagan
Mar 13, 2013·Forensic Science International : Synergy·Danielle S FisherRobert J Flanagan
Jan 14, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel SistikPetr Bednar
Dec 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisbeth PatteetHugo Neels
May 11, 2016·Clinical Biochemistry·Maria Shipkova, Dobrin Svinarov
Feb 29, 2020·Drug Testing and Analysis·Maximilian MethlingSven Hartwig
Mar 27, 2021·Drug Metabolism and Personalized Therapy·Marek DziadoszJörg Teske
Aug 20, 2021·Drug Metabolism and Personalized Therapy·Marek DziadoszJörg Teske

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