The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes

Doklady. Biochemistry and Biophysics
Y A ShelyginN I Pospekhova

Abstract

The expression levels of microRNAs miR-200c and miR-145 in two groups of colorectal cancer differing by the presence/absence of epithelial-mesenchymal transition (EMF) were studied. In the EMF-positive cancer, the level of miR-145 is increased, whereas the level of miR-200c is reduced. The reverse situation is observed in the EMI-negative cancer. MiR-145 can serve as a marker of the mesenchymal subtype of cancer. Gene expression profiles and microRNAs allow prognostically unfavorable tumors of the mesenchymal subtype to be distinguished.

References

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Citations

Nov 15, 2017·The Korean Journal of Internal Medicine·Yunsuk ChoiJe-Hwan Lee
Jul 16, 2019·International Journal of Cancer. Journal International Du Cancer·Susanna ZanuttoManuela Gariboldi

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