Feb 1, 2018

The Analysis of Polyploid Genetic Data

The Journal of Heredity
Patrick G MeirmansP H Van Tienderen

Abstract

Though polyploidy is an important aspect of the evolutionary genetics of both plants and animals, the development of population genetic theory of polyploids has seriously lagged behind that of diploids. This is unfortunate since the analysis of polyploid genetic data-and the interpretation of the results-requires even more scrutiny than with diploid data. This is because of several polyploidy-specific complications in segregation and genotyping such as tetrasomy, double reduction, and missing dosage information. Here, we review the theoretical and statistical aspects of the population genetics of polyploids. We discuss several widely used types of inferences, including genetic diversity, Hardy-Weinberg equilibrium, population differentiation, genetic distance, and detecting population structure. For each, we point out how the statistical approach, expected result, and interpretation differ between different ploidy levels. We also discuss for each type of inference what biases may arise from the polyploid-specific complications and how these biases can be overcome. From our overview, it is clear that the statistical toolbox that is available for the analysis of genetic data is flexible and still expanding. Modern sequencing tech...Continue Reading

  • References68
  • Citations5

References

Mentioned in this Paper

Nucleic Acid Sequencing
Cell Differentiation Process
Sequencing
Polyploidy-Inducing Agents
Complication
Tetrasomy
Structure
Simulation
Analysis
Polyploidy

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