PMID: 11923995Apr 2, 2002Paper

The analysis of repeated multivariate binary quality of life data: a hierarchical model approach

Statistical Methods in Medical Research
H J Ribaudo, S G Thompson

Abstract

Many quality of life measuring instruments consist of a number of questions that are answered on ordinal scales. Often these responses are then totalled to give a summary score for each quality of life domain within the instrument. This, however, may lose valuable information about individual aspects of patient quality of life and also can have little intuitive meaning. Here we present an alternative analysis, in which dichotomized individual items of the questionnaire are analyzed. We first show how a hierarchical logistic regression model for repeated binary data can be extended to the multivariate case. We then use such a model for analyzing the prevalence of six symptoms in a palliative treatment trial in non-small-cell lung cancer. The analysis provides information about the correlations between symptoms, both between and within person. If appropriate, it also permits the estimation of a treatment effect common to all symptoms. Methods for model checking are discussed. We conclude that this methodology can provide a more intuitive and informative analysis of quality of life data than that obtained by considering summary scores.

References

Oct 1, 1983·Statistics in Medicine·P M Fayers, D R Jones
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 1, 1994·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·P HopwoodD Machin
Dec 15, 1996·Statistics in Medicine·T R Ten HaveJ Hartzel
Apr 29, 1998·Statistics in Medicine·D CurranR J Sylvester

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Citations

Jan 22, 2009·Statistics in Medicine·Keunbaik LeeJungBok Lee
Aug 19, 2016·PloS One·Eric Houngla AdjakossaGregory Nuel
Apr 24, 2012·Statistical Methods in Medical Research·Geert VerbekeMarie Davidian
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Katherine J Lee, Simon G Thompson
Jul 19, 2006·Biometrical Journal. Biometrische Zeitschrift·Rebecca M TurnerSimon G Thompson
Sep 21, 2006·Biometrics·Bernhard Klingenberg, Alan Agresti
Dec 2, 2005·Statistics in Medicine·Beatrijs MoerkerkeVeronique Cocquyt
Feb 8, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stephen D FlachBradley N Doebbeling
Jul 12, 2019·Statistical Methods in Medical Research·Jaeil Ahn, Hye Seong Ahn

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