The analysis of selected neurotransmitter concentrations in serum of patients with Tourette syndrome

Neurologia i neurochirurgia polska
Piotr JanikHubert Kwieciński

Abstract

Metabolic disturbances of excitatory and inhibitory neurotransmitters are implicated in pathogenesis of Tourette syndrome (TS). The aim of the study was to measure serum concentrations of glutamic acid, g-aminobutyric acid (GABA) and glycine in TS patients and evaluate any correlation between neurotransmitter levels and age at onset, actual age, gender, tic severity, duration of the disease and concomitant psychiatric disorders. Sixty-seven TS patients, aged 16-59, and 57 healthy controls, aged 19-37, were enrolled in the study. Information regarding medical history and physical investigation was collected using a short questionnaire. Sixty-seven percent of patients were medication-free at the time of examination and the rest had withheld treatment for 24 hours before. Blood samples were taken after a 12-hour fasting period. HPLC technique was used. The TS group had higher glutamic acid and lower GABA levels. Glycine concentrations were comparable. No differences regarding neurotransmitter concentrations between treated and non-treated patients were found. Patients with concomitant obsessive-compulsive disorder and severe tics had higher glutamate levels. Glutamate concentrations correlated positively with the number of comorbi...Continue Reading

References

May 11, 1979·Brain Research·P BöhlenM G Palfreyman
Oct 1, 1986·Acta Neurologica Scandinavica·S UhlhaasK Olek
Apr 1, 1982·Journal of Neurochemistry·W Löscher, H H Frey
Feb 1, 1980·Neuropharmacology·H H Frey, W Löscher
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C CepedaM S Levine
May 15, 1998·The American Journal of Physiology·W J LeeD R Peterson
Jun 25, 1998·Neuropediatrics·G F HoffmannR A Wevers
Dec 1, 1999·Molecular Psychiatry·F PettyA J Rush
Feb 25, 2000·Brain : a Journal of Neurology·M M Robertson
Oct 12, 2001·Journal of Neurochemistry·A KakeeY Sugiyama
Apr 4, 2002·Journal of Neurophysiology·Enrico BracciPaolo Calabresi
Oct 17, 2002·Journal of Studies on Alcohol·Nadir N Aliyev, Zafar N Aliyev
Jul 19, 2003·Current Opinion in Neurology·Tamara PringsheimAnthony Lang
Dec 1, 1958·Journal of Neurochemistry·N M VAN GELDER, K A ELLIOTT
Jan 17, 2004·Acta Psychiatrica Scandinavica·J Serra-MestresM R Trimble
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin PeiFang Liu
Oct 27, 2004·The Journal of Nervous and Mental Disease·Barbara J CoffeyStephen V Faraone
Dec 21, 2005·The Journal of Nutrition·Richard A HawkinsJuan R Viña
Jul 26, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Atsuko ShinoheNorio Mori
Sep 15, 2006·Journal of Child Neurology·Kendra Harris, Harvey S Singer
Aug 4, 2009·Journal of the Neurological Sciences·Mikhail F ChernovKintomo Takakura

❮ Previous
Next ❯

Citations

Sep 1, 2015·Journal of Affective Disorders·Fengyuan CheYifeng Du
Aug 26, 2020·Journal of the American Society for Mass Spectrometry·Nolan McLaughlinKatherine A Stumpo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Journal of Psychosomatic Research
Mary M Robertson
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Rong JinZu-mu Zhou
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Li-Ping ZouHang-Yan Wang
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Rocco RaffaeleLiborio Rampello
© 2021 Meta ULC. All rights reserved