The analysis of the defense mechanism against indigenous bacterial translocation in X-irradiated mice

Microbiology and Immunology
T KobayashiK Nomoto

Abstract

The defense mechanism against indigenous bacterial translocation was studied using a model of endogenous infection in X-irradiated mice. All mice irradiated with 9 Gy died from day 8 to day 15 after irradiation. The death of mice was observed in parallel with the appearance of bacteria from day 7 in various organs, and the causative agent was identified to be Escherichia coli, an indigenous bacterium translocating from the intestine. Decrease in the number of blood leukocytes, peritoneal cells and lymphocytes in Peyer's patches or mesenteric lymph nodes was observed as early as 1 day after irradiation with 6 or 9 Gy. The mitogenic response of lymphocytes from various lymphoid tissues was severely affected as well. The impairment of these parameters for host defense reached the peak 3 days after irradiation and there was no recovery. However, in vivo bactericidal activity of Kupffer cells in mice irradiated with 9 Gy was maintained in a normal level for a longer period. It was suggested that Kupffer cells play an important role in the defense against indigenous bacteria translocating from the intestine in mice.

Citations

May 7, 1998·Microbiology and Immunology·T KobayashiM Mitsuyama
Mar 31, 2015·Expert Opinion on Drug Discovery·Vijay K SinghThomas J MacVittie
Mar 10, 2001·The British Journal of Nutrition·H KorhonenH S Gill
Apr 27, 2017·Expert Opinion on Drug Discovery·Vijay K Singh, Ayodele O Olabisi
Jan 29, 2020·The Journal of Pathology·William H McBride, Dörthe Schaue
Dec 1, 2005·The Journal of Nutrition·Hiroyuki MizubuchiYasunobu Yoshikai
Mar 26, 2010·Radiation Research·Jacqueline P WilliamsWilliam H McBride

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