Abstract
Human leukocyte antigen (HLA) alleles have been associated with an increased or decreased risk of developing cervical cancer through infection with oncogenic forms of the human papillomavirus (HPV). The aim of this study was to analyze the interactions between HPV and HLA, particularly of the entire HLA and partial non-HLA regions, in invasive cervical cancers. The results showed the distribution of HPV genotypes among patients with cervical cancer in this group: the overall prevalence of HPV DNA was 91.3% (274/300). A total of 16 HPV genotypes, HPV16, 18, 58, 33, 81, 31, 68, 39, 67, 6, 11, 26, 52, 62, 66, and 70, were detected in patients with cervical cancer. Among the cervical cancer specimens, 68.7% were positive for HPV16. Genotyping was performed with 112 microsatellite markers spanning the entire HLA region and partial region of chromosome 6q15-16.3. D6S2766 and D6S2764, which are located near to the region containing the HLA-DPB genes, were negatively related with cervical cancer (OR for the D6S2766-195 allele carriers = 0.50), and positively related with cervical cancer (OR for the D6S2764-209 allele carriers = 2.44), respectively. Significant association was found for D6S1043 (allele 132) with HPV16-positive cervical ...Continue Reading
References
Aug 22, 1991·Nature·R Wank, C Thomssen
Jan 1, 1994·Tissue Antigens·A Svejgaard, L P Ryder
Feb 1, 1994·Nature Genetics·R J AppleC M Wheeler
Nov 15, 1996·International Journal of Cancer. Journal International Du Cancer·C B SanjeeviA Lernmark
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Apr 6, 2002·Human Genetics·Akira TsujimuraShiro Takahara
May 14, 2004·Genome Research·C Andrew StewartStephan Beck
Jun 10, 2004·Genes, Chromosomes & Cancer·Hugo Arias-PulidoCosette M Wheeler
Jul 9, 2004·Human Molecular Genetics·Malin EngelmarkUlf Gyllensten
Jul 22, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Nov 18, 2004·Tissue Antigens·T ShiinaJ K Kulski
Jan 22, 2005·Human Immunology·Steven G E Marsh
Aug 3, 2005·Journal of Medical Genetics·M ZoodsmaA G J van der Zee
Sep 27, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yuping WuYing He
Sep 28, 2005·Tissue Antigens·J D CarreonS S Wang
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Paul K S ChanShing-Shun N Siu
Oct 20, 2005·The Journal of Infectious Diseases·Denise P C ChanPaul K S Chan
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Yuping WuAnlong Xu
Apr 11, 2006·The Journal of General Virology·Yuping WuYanling Zhang
Feb 22, 2007·Journal of Medical Virology·Yuping WuAnlong Xu
May 23, 2007·Journal of Medical Virology·Paul K S ChanJulian W Tang
Oct 16, 2007·Journal of Medical Virology·Efstathia PanotopoulouGeorge Magiakos
Citations
Sep 18, 2012·The American Journal of Pathology·De-Wei WuHuei Lee
Apr 11, 2018·Oncotarget·Hui-Hui XuWei-Hua Yan
Aug 28, 2020·Frontiers in Genetics·Nicole WynerDennis McNevin