The analysis of the zero-order and the second derivative spectra of retinol acetate, tocopherol acetate and coenzyme Q10 and estimation of their analytical usefulness for their simultaneous determination in synthetic mixtures and pharmaceuticals

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
J Karpińska, Beata Mularczyk

Abstract

The aim of the present work was to develop a simple and rapid method of retinol acetate, tocopherol acetate and coenzyme Q(10) determination in pharmaceuticals without involving any preparation operations like separation or masking. The values of second derivative amplitude at 212 nm for tocopherol, 351 nm for retinol and 222 nm for coenzyme were used for construction of calibration graphs. Beer's law is obeyed in the concentration range 0.5-20, 0.5-7.5 and 0.5-30 microg ml(-1) for retinol acetate, tocopherol acetate and coenzyme, respectively. The elaborated procedures were successfully applied to the simultaneous determination of studied compounds in their binary synthetic mixtures and in commercial preparations with high reliability and repeatability. Spectral properties of retinol acetate allows to determine its contents in ternary mixture which includes Vitamin E and coenzyme Q(10).

References

Aug 22, 1997·Journal of Chromatography. a·S Albalá-HurtadoA Mariné-Font

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Citations

Dec 11, 2008·Analytical and Bioanalytical Chemistry·Naoya KishikawaNaotaka Kuroda
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Žane Temova RakušaRobert Roškar
Jun 15, 2005·Analytical Chemistry·R K Gilpin, L A Pachla
Feb 10, 2009·Analytica Chimica Acta·F Sánchez Rojas, C Bosch Ojeda

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