PMID: 29783252May 22, 2018Paper

The analytical prognosis of the susceptibility to aminoglycosides and doxycycline inacinetobacter baumanniiisoolated from burns of intensive care unit patients

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Vasyl I NahaichukHalyna H Nazarchuk

Abstract

Introduction: Clinical strains of A.baumannii are becoming highly important in hospital-acquired infections, especially because of their association with low susceptibility to antibiotics, which requires in-depth study with a prognostic determination of the dynamics of antimicrobial efficacy of antibiotics. The aim was to investigate of prognostic models of aminoglycoside antibiotics effectiveness on the basis of the mathematical analysis of real susceptibility of A.baumannii clinical strains, isolated from patients in BICU. Materials and methods: In the research there were enrolled 435 patients who had undergone treatment of the 2ndb - 3rd degree burns at the burn department of the Vinnitsa Regional Clinical Hospital N. I. Pirogov during 2011-2016. In total, 222 clinical strains of A.baumannii were isolated in early period after burn trauma before antibiotic therapy. The susceptibility of clinical strains A.baumannii to the gentamicin, tobramycin, amikacin, doxycycline was defined by qualitative disco-diffusion and quantitative double dilution methods. Results: The results of the study demonstrated a low susceptibility of clinical strains of A.baumannii to the studied aminoglicosides and doxycycline. During 2011-2016 the highe...Continue Reading

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