The anatomic distribution of malignant and premalignant glottic lesions and its relations to smoking

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Hagit Shoffel-HavakukYonatan Lahav

Abstract

To describe the anatomic location and distribution of glottic dysplasia and early glottic cancer. Case series with chart review. Tertiary care referral center. Review of 167 glottic dysplasia or carcinoma patients between 2008 and 2013. Lesions were described in terms of location and size, and a novel grid system was used to map out anatomic distribution. Seventy-eight patients with dysplasia and 89 with early glottic carcinoma were included. One hundred twenty-eight were smokers and 39 nonsmokers. The medial aspect of the vocal fold was more involved than the superior aspect, 95% versus 71%, respectively (P < .001). The superior aspect was more involved in smokers, 77% versus 51% in nonsmokers (P = .0016). Using a grid system, the most involved area was the midpoint of the membranous vocal fold at the transition between the superior and medial aspects. Ninety-seven percent of the lesions occupied this specific area, with no difference between smokers and nonsmokers. The vocal process mucosa was involved in 48 patients. Exclusive vocal process involvement was limited to 2 cases. All other 46 patients demonstrated extensive disease, encompassing more than half of the vocal fold's length. Carcinomatous lesions tended to be larger...Continue Reading

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Citations

Aug 27, 2015·Inhalation Toxicology·Hagit Shoffel-HavakukYonatan Lahav
Mar 10, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Andrew J KinshuckTerry M Jones
May 16, 2019·The Laryngoscope·Hagit Shoffel-HavakukYonatan Lahav

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