The anatomy of the human medial forebrain bundle: Ventral tegmental area connections to reward-associated subcortical and frontal lobe regions

NeuroImage. Clinical
Volker A CoenenMarco Reisert

Abstract

Despite their importance in reward, motivation, and learning there is only sparse anatomical knowledge about the human medial forebrain bundle (MFB) and the connectivity of the ventral tegmental area (VTA). A thorough anatomical and microstructural description of the reward related PFC/OFC regions and their connection to the VTA - the superolateral branch of the MFB (slMFB) - is however mandatory to enable an interpretation of distinct therapeutic effects from different interventional treatment modalities in neuropsychiatric disorders (DBS, TMS etc.). This work aims at a normative description of the human MFB (and more detailed the slMFB) anatomy with respect to distant prefrontal connections and microstructural features. Healthy subjects (n = 55; mean age ± SD, 40 ± 10 years; 32 females) underwent high resolution anatomical magnetic resonance imaging including diffusion tensor imaging. Connectivity of the VTA and the resulting slMFB were investigated on the group level using a global tractography approach. The Desikan/Killiany parceling (8 segments) of the prefrontal cortex was used to describe sub-segments of the MFB. A qualitative overlap with Brodmann areas was additionally described. Additionally, a pure visual analysis wa...Continue Reading

Citations

Aug 24, 2019·Brain Structure & Function·Jonas A HospM Reisert
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Jul 7, 2020·Operative Neurosurgery·Maria Guadalupe García-GomarFrancisco Velasco-Campos
Aug 23, 2019·Translational Psychiatry·Volker A CoenenMarco Reisert
Sep 19, 2018·Attention Deficit and Hyperactivity Disorders·Sarah BaumeisterDaniel Brandeis
Dec 20, 2018·Cognitive, Affective & Behavioral Neuroscience·Carlo LaiPaola Aceto
Jun 6, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rodrigo C MarquesAmaury Cantilino
Mar 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Volker A CoenenThomas E Schlaepfer
Feb 2, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Miklos PalotaiCharles R G Guttmann
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