The ancestral circadian clock of monarch butterflies: role in time-compensated sun compass orientation

Cold Spring Harbor Symposia on Quantitative Biology
Steven M Reppert

Abstract

The circadian clock has a vital role in monarch butterfly (Danaus plexippus) migration by providing the timing component of time-compensated sun compass orientation, which contributes to navigation to the overwintering grounds. The location of circadian clock cells in monarch brain has been identified in the dorsolateral protocerebrum (pars lateralis); these cells express PERIOD, TIMELESS, and a Drosophila-like cryptochrome designated CRY1. Monarch butterflies, like all other nondrosophilid insects examined so far, express a second cry gene (designated insect CRY2) that encodes a vertebrate-like CRY that is also expressed in pars lateralis. An ancestral circadian clock mechanism has been defined in monarchs, in which CRY1 functions as a blue light photoreceptor for photic entrainment, whereas CRY2 functionswithin the clockwork as themajor transcriptional repressor of an intracellular negative transcriptional feedback loop. A CRY1-staining neural pathway has been identified that may connect the circadian (navigational) clock to polarized light input important for sun compass navigation, and a CRY2-positive neural pathway has been discovered that may communicate circadian information directly from the circadian clock to the centr...Continue Reading

References

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Citations

Feb 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kenji TomiokaTaishi Yoshii
Apr 27, 2013·Integrative and Comparative Biology·Adam M ReitzelOren Levy
May 28, 2013·Integrative and Comparative Biology·Ann M Tarrant, Adam M Reitzel
Oct 26, 2013·Frontiers in Neuroendocrinology·Vincent M Cassone
Jul 16, 2010·Trends in Neurosciences·Steven M ReppertChristine Merlin
May 12, 2009·Behavioural Brain Research·Jakub SpätiChristian Cajochen
Oct 3, 2008·Insect Molecular Biology·F SandrelliE Rosato
Jan 26, 2011·Neuron·Stanley Heinze, Steven M Reppert
Oct 27, 2011·New Directions for Youth Development·Dale A Blyth, Laura LaCroix-Dalluhn
Oct 11, 2019·Journal of Biological Rhythms·Lauren E Foley, Patrick Emery
Jan 16, 2021·Journal of Biological Rhythms·Kandis L AdamsJacobus C de Roode

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