The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells

Stem Cells International
Alastair H Davies, Amina Zoubeidi

Abstract

The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of "core" transcription factors for maintaining the stem cell state. It is now clear that stem cell regulatory networks are far more complex. In this review, we examine the role of the androgen receptor (AR) in coordinating interactions between signaling nodes that govern the balance of cell fate decisions in prostate stem cells.

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Citations

Feb 21, 2018·Nature Reviews. Urology·Alastair H DaviesAmina Zoubeidi
May 22, 2020·Breast Cancer Research and Treatment·Cristian ScatenaAntonio Giuseppe Naccarato
Jun 13, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Feng ChenSoo Ok Lee
May 1, 2021·International Journal of Molecular Sciences·Cristina LupuFlorea Lupu

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Methods Mentioned

BETA
xenografts

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