PMID: 1212219Oct 1, 1975Paper

The androgenic regulation of the activities of enzymes engaged in the synthesis of deoxyribonucleic acid in rat ventral prostate gland

The Biochemical Journal
P S RennieW I Mainwaring

Abstract

The restoration of mitosis and growth of the prostate gland of castrated animals by androgens provides a favourable experimental system for studying the hormonal regulation of enzymes engaged in DNA replication. 2. Many DNA polymerase activities were identified in the prostate gland, but only a 9S form with a particular preference for denatured DNA as template was conspicuously enhanced by androgenic stimulation. 3. Thymidine kinase also provided a sensitive indicator of the hormonal regulation of DNA replication, and on electrophoretic criteria, one discrete form of the enzyme appeared precisely with the onset of mitoris. 4. Evidence is presented to support the view that DNA ligase activity is intimately associated in the process of DNA replication in the prostate gland. 5. A spectrum of deoxyribonuclease activities is present in the prostate gland, but only one form (pI7.0) can safely be said to be implicated in the process of DNA replication. 6. Androgenic stimulation of the prostate gland leads to the appearance of a component capable of denaturing or unwinding prostate DNA. This component is seemingly distinct from RNA or DNA polymerase activities on the basis of several distince physicochemical characteristics. 7. The con...Continue Reading

Citations

Apr 17, 1978·European Journal of Biochemistry·M G Parker, G T Scrace
Jan 1, 1995·International Urology and Nephrology·V L Kumar, P K Majumder
Nov 1, 1982·Applied Biochemistry and Biotechnology·T T NgoJ Ivy
Sep 1, 2004·Environmental Health and Preventive Medicine·Kazuko IchieYuzo Sato
Jul 26, 1977·Archives of Microbiology·M Rupprecht, K H Schleifer
Jan 1, 1981·The Histochemical Journal·M J KarnovskyM L Karnovsky
Jan 1, 1994·Critical Reviews in Microbiology·M F Reid, C A Fewson
Jun 15, 2012·Journal of Biomolecular Structure & Dynamics·Joydeep ChakrabortyTapan K Dutta
May 1, 1986·Molecular and Cellular Endocrinology·M G GilesN Bruchovsky
Jul 1, 1979·Journal of Steroid Biochemistry·P DaviesK Griffiths
Dec 1, 1977·Molecular and Cellular Endocrinology·P S RennieN Bruchovsky
May 1, 1978·Molecular and Cellular Endocrinology·J N Harris, J Gorski
Jul 1, 1978·Journal of Steroid Biochemistry·P S RennieS L Hook

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