PMID: 518182Dec 1, 1979Paper

The Angell-Shiley porcine xenograft

The Annals of Thoracic Surgery
W W AngellA Sywak

Abstract

A 4-year clinical experience with fresh allograft tissue valves prompted a trial of 0.5% buffered glutaraldehyde as a valve fixative and sterilant. Tanned allograft and porcine xenograft valves were inserted into experimental animals, and, beginning in 1970, similar valves were implanted in a series of patients now totaling 312. The clinical results are excellent. The 5-year valve-related mortality is 6% for patients who had mitral valve replacement and 16% for those with aortic valve replacement. To date, the incidence of thromboembolism is 1.3% per patient-year, and valve-related morbidity and mortality for the combined groups is 27.4%. Valve stent design has evolved from symmetrically configured metal to anatomically molded plastic. The maintenance of natural valve configuration has optimized leaflet coaptation and support, decreased tissue stress, and eliminated valve-stent dehiscence and tissue rupture seen in valves deformed to fit symmetrical stents. Stent design, controlled glutaraldehyde solutions, and fixation techniques have improved leaflet flexibility and reduced valve orifice to annulus diameter ratios, thus producing transvalvular gradients comparable to both mechanical and modified orifice tissue valves. To date...Continue Reading

References

Feb 1, 1978·Thorax·A G RoseR M Bowen

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Citations

Aug 1, 1981·The Annals of Thoracic Surgery·R M BeckerR W Frater
May 24, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jagdish ButanyRichard L Leask
Sep 1, 1980·Progress in Cardiovascular Diseases·W W Angell, J D Angell
Nov 1, 1980·The Annals of Thoracic Surgery·R RiveraM Rico
Apr 1, 1982·The Annals of Thoracic Surgery·L NuñezJ L Larrea
Jan 1, 1982·Annals of Biomedical Engineering·F J SchoenG M Lawrie
Mar 23, 2017·Cold Spring Harbor Perspectives in Medicine·Alessandra CostaStephen F Badylak
Jan 1, 1980·Catheterization and Cardiovascular Diagnosis·P R Febres-RomanG D Cowen

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