The angiogenic effects of ischemic conditioning in experimental critical limb ischemia

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
R KarakoyunZ Sener

Abstract

Ischemic conditioning (IC) is a method of angiogenic stimulus for limb ischemia. Here, we aimed to investigate the effects of short-term repeated ischemic stimulus on critical lower limb ischemic injury. Rats were divided into four groups consisting of 40 animals in each group: sham, ischemia, local IC, and remote IC groups. Right-leg critical limb ischemia was achieved through ligation of the iliac artery and vein in male Sprague-Dawley rats except the sham group. Repeated transient ischemia using the tourniquet method was used for IC of lower extremities in the local and remote groups. IC was performed on the right leg for the local group and on the left leg for the remote group. Ten rats in each group were sacrificed for evaluation on days 1, 7, 14, and 30. Endothelial progenitor cell (EPC) counts were measured. Gastrocnemius muscles were evaluated for the degree of ischemia. Laser Doppler blood flow measurements were performed in order to make comparison between the blood flows of the limbs of the groups. The blood flow in the right limb of rats in the sham (1.65 perfusion units [PU]) and local IC (1.67 PU) groups was significantly higher than the ischemic group (1.17 PU) (p = .001 and p = .022 respectively). The levels of ...Continue Reading

References

Feb 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Lepäntalo, S Mätzke
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Oct 11, 2002·Microsurgery·Markus V KüntscherGünter Germann
Dec 4, 2002·Circulation·R K KharbandaR MacAllister
Jul 3, 2003·Annals of Plastic Surgery·Markus V KüntscherGünter Germann
Mar 11, 2004·Journal of Reconstructive Microsurgery·Wei Z WangWilliam A Zamboni
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas WaldowKlaus Matschke
Apr 22, 2008·Cell·Adam T BoutinRandall S Johnson
Nov 26, 2008·Journal of Vascular Surgery·Tormod S WestvikAlan Dardik
Dec 2, 2008·The Journal of Surgical Research·Niteen TapuriaBrian R Davidson
Oct 5, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anders R KnudsenFrank V Mortensen
Dec 4, 2010·Atherosclerosis·Claudio NapoliLouis J Ignarro
Jun 8, 2011·Vascular and Endovascular Surgery·Hisato Takagi, Takuya Umemoto
Sep 9, 2011·The Journal of Physiological Sciences : JPS·Kenki EnkoHiroshi Ito
Nov 10, 2011·The British Journal of Surgery·N A MughalS Homer-Vanniasinkam
Mar 1, 2012·Journal of Cellular and Molecular Medicine·Mohamad Amer AlaitiMarco A Costa
Nov 9, 2012·International Journal of Biological Sciences·Bin JiangYan-gao Man

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Citations

Mar 18, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G GökalpO Gökalp
Jan 24, 2018·Stem Cells International·Punam P ParikhOmaida C Velazquez
Dec 27, 2019·PloS One·André Luiz Pinto Dos SantosMoacyr Cunha Filho
Jul 22, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chang Sik PakHyo Jin Kang
Mar 25, 2017·Molecular Medicine Reports·Meng ZhouHuiliang Shen
Feb 4, 2021·Acta Cirúrgica Brasileira·Edson Yuzur YasojimaSérgio Cunha Trindade Júnior

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