The angiogenic switch: implications in the regulation of tumor dormancy

Current Molecular Medicine
L MoserleStefano Indraccolo

Abstract

Angiogenesis plays an established role in the growth promotion of dormant micrometastasis, because blood vessels deliver oxygen and nutrients into the tumor microenvironment. A discrete event termed "the angiogenic switch" has been recognized as key in promoting the transition towards a clinically aggressive tumor. This concept generally describes a permanent change in the angiogenic capacity of the tumor sustained by genetic events occurring in cancer cells. Recent evidence, however, indicates that a transient angiogenic switch delivered by components of the tumor microenvironment can also convey tumorigenic properties to tumor cells. Why is the angiogenic switch so fundamental in the promotion of tumor growth? In addition to the recognized feeding function of blood vessels, there is accumulating evidence suggesting that endothelial cells - and perhaps other cellular components of the microenvironment - communicate both positive and negative signals to tumor cells. This cross-talk between heterogeneous cell types could turn out to be important in the regulation of cancer cells' behaviour. In this review, we discuss the possible implications of the angiogenic switch on our understanding of the regulation of tumor dormancy.

Citations

Jun 21, 2011·Seminars in Immunopathology·Douglas D Taylor, Cicek Gercel-Taylor
Sep 13, 2012·PloS One·Ronit Satchi-FainaroNava Almog
Oct 17, 2013·PloS One·Jennifer D ElsterEdward V Prochownik
Apr 6, 2011·Future Oncology·Esther BridgesAdrian Harris
Apr 17, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Gang GuoZhong-ze Fan
Apr 7, 2010·Cancer Letters·Nava Almog
Jan 13, 2011·Pediatric Blood & Cancer·Li-Zhi ZhangBing-Fang Zeng
Dec 3, 2013·Autoimmune Diseases·Norma Y Hernández-PedroJulio Sotelo
Aug 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ali Mohammad AlizadehSadaf Farsinejad
Dec 3, 2014·Experimental Cell Research·Daniela BelloniElisabetta Ferrero
Mar 20, 2013·Biochimie·Sandy Giuliano, Gilles Pagès
Feb 7, 2015·Critical Reviews in Oncology/hematology·Antonio GnoniVito Lorusso
Aug 21, 2013·Critical Reviews in Oncology/hematology·Wim CeelenMarc Mareel
Oct 12, 2013·Journal of Cancer Research and Clinical Oncology·Zhaoguo LiuYin Lu
Jun 2, 2011·Nature Reviews. Clinical Oncology·Katrien De BockPeter Carmeliet
Feb 6, 2010·Expert Review of Anticancer Therapy·Kanya Honoki
Aug 10, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lorenzo VeschiniElisabetta Ferrero
Sep 21, 2016·International Anesthesiology Clinics·James FreemanDonal Buggy
Jan 3, 2020·International Journal of Molecular Medicine·Charlotte FlühJanka Held-Feindt
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Anna Julia WiecekMaria Secrier
Aug 14, 2021·Advanced Drug Delivery Reviews·Victoria LaiJoshua C Doloff

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