PMID: 9178851May 9, 1997Paper

The angiotensin AT2 receptor down-regulates neurofilament M in PC12W cells

Neuroscience Letters
S GallinatThomas Unger

Abstract

The angiotensin (ANG II) AT2 receptor mediates antiproliferative effects and induces neurite outgrowth in PC12W cells. To further investigate the molecular events following AT2 receptor stimulation in these cells, we determined the expression pattern of the middle-sized neurofilament subunit (NF-M) using Western and Northern blot analysis and reverse-transcription polymerase chain reaction. On both, the protein and the mRNA level, ANG II via AT2 receptors not only counteracted nerve growth factor (NGF)-mediated NF-M up-regulation but also reduced NF-M levels in the absence of NGF by maximally 72%. The ANG II-induced effects were completely abolished by pretreatment with the AT2 receptor antagonist, PD123177. In view of previous findings of decreased NF levels in regenerating neurons and in neuronal cultures undergoing apoptosis, our observation suggests a new role of AT2 receptors in either of these processes.

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Citations

Jul 20, 2004·Current Hypertension Reports·Christa Thöne-ReinekeThomas Unger
Sep 12, 2000·Current Hypertension Reports·R M CareyH M Siragy
Jun 1, 2001·Regulatory Peptides·M Stoll, T Unger
Jul 8, 1999·Regulatory Peptides·M de Gasparo, H M Siragy
Jun 26, 2001·The British Journal of Dermatology·H Takeda, S Kondo
Sep 15, 1998·Kidney International. Supplement·O ChungT Unger
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·A BlumeT Unger
Jan 15, 2014·Current Hypertension Reports·Pawel NamsolleckThomas Unger
Jul 27, 2005·Peptides·U M SteckelingsTh Unger
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·J CulmanT Unger
Feb 24, 1999·Journal of Cardiovascular Pharmacology·U Stroth, T Unger
Sep 23, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kirstin ReineckeThomas Unger
Mar 7, 2000·Journal of Hypertension·T Unger
Jun 30, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Henrik WilmsRalph Lucius
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·S GallinatC Sumners
Jul 22, 2021·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bryan Jael CollazoYamil Gerena

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis