The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms

Clinical Hypertension
Craig Steven McLachlan

Abstract

There is current debate concerning the use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (ARBs), for hypertension management, during COVID-19 infection. Specifically, the suggestion has been made that ACE inhibitors or ARBs could theoretically contribute to infection via increasing ACE2 receptor expression and hence increase viral load. The ACE2 receptor is responsible for binding the SAR-CoV2 viral spike and causing COVID-19 infection. What makes the argument somewhat obtuse for ACE inhibitors or ARBs is that ACE2 receptor expression can be increased by compounds that activate or increase the expression of SIRT1. Henceforth common dietary interventions, vitamins and nutrients may directly or indirectly influence the cellular expression of the ACE2 receptor. There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D. It is important to acknowledge that down-regulation or blocking the cellular ACE2 receptor will likely be pro-inflammatory and may contribute to end organ pathology and mortality in COVID-19. In conclusion from the perspective of the ACE2 receptor, COVID-19 prevention and t...Continue Reading

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Citations

Oct 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elijah StoneCraig S McLachlan
Dec 10, 2020·Clinical and Translational Allergy·Jean BousquetUNKNOWN ARIA group
Mar 21, 2021·Open Heart·James J DiNicolantonioJorge Barroso-Aranda
Apr 8, 2021·Channels·Wentong LongPeter Light
Dec 15, 2020·Trends in Biochemical Sciences·Thi Khanh LePalma Rocchi
Apr 20, 2021·Frontiers in Endocrinology·David J EastyBryan T Hennessy
Jun 4, 2021·Tissue Engineering and Regenerative Medicine·Felipe Allan da Silva da CostaJoão Tadeu Ribeiro-Paes
Jun 2, 2021·Journal of Medical Virology·Shireen NigarM Anwar Hossain
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Jul 20, 2021·Journal of Basic and Clinical Physiology and Pharmacology· RufaidaSaba Parveen

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