The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease

Clinical Biochemistry
Asad Vaisi-RayganiTayebeh Pourmotabbed

Abstract

The role of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in early onset coronary artery disease age < 55years (ECAD) is controversial. The aim of this study was to further evaluate the role of this ACE(I/D) gene polymorphism on the risk of premature CAD in patients from western Iran. The ACE(I/D) genotypes were detected by PCR-RFLP in 323 individuals undergoing their first coronary angiography. Patients were placed into two groups: ECAD and late onset CAD age ≥ 55years (LCAD). We found a statistically significant association of the ACE D allele, as homozygous or ACE ID plus DD genotypes (ID+DD), only in the ECAD subjects OR=1.35, p=0.015, OR=3.27, p=0.014, and OR=2.8, p=0.013, respectively. In addition, there was a significant association after adjustment for the absence of history of diabetes, presence of normolipidemia and absence of history of blood pressure [OR 1.38, p=0.017 and 2.35, p=0.02]. Our results indicated that the ACE D allele is a risk factor for early onset of CAD even after correcting for conventional risk factors. The incidence of triple vessel disease was significantly higher in individuals carrying ACE(D/D) genotype in ECAD patients compared to those who carried ACE(I/I) gen...Continue Reading

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Citations

May 27, 2011·Age·Matea Zajc PetranovićSpomenka Tomek-Roksandić
Apr 30, 2013·Ageing Research Reviews·Nuria GaratacheaAlejandro Lucia
Feb 24, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Irma Isordia-SalasAbraham Majluf-Cruz
Dec 21, 2018·Omics : a Journal of Integrative Biology·Jean Jacques NoubiapAmbroise Wonkam
Jun 28, 2016·The Open Cardiovascular Medicine Journal·Zulkuf KarahanFerit Ozdemir
May 1, 2019·European Journal of Clinical Investigation·Hoorak PoorzandNegar Morovatdar
Nov 7, 2019·Current Pharmaceutical Design·Huilei ZhengXiaoling Qiu
Oct 24, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Evgeny A ReshetnikovMikhail I Churnosov
Jun 23, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Shu-hong DaiDa-qing Li

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