PMID: 11907153Mar 22, 2002Paper

The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension

The Journal of Pharmacology and Experimental Therapeutics
Christian T AbrahamsenDavid P Brooks

Abstract

The effects of the angiotensin type 1 (AT(1)) receptor antagonist, eprosartan, were studied in a model of severe, chronic hypertension. Treatment of male spontaneously hypertensive stroke prone rats (SHR-SP) fed a high-fat, high-salt diet with eprosartan (60 mg/kg/day i.p.) for 12 weeks resulted in a lowering of blood pressure (250 +/- 9 versus 284 +/- 8 mm Hg), renal expression of transforming growth factor-beta mRNA (1.5 +/- 0.2 versus 5.4 +/- 1.4) and the matrix components: plasminogen activator inhibitor-1 (5.2 +/- 1.4 versus 31.4 +/- 10.7), fibronectin (2.2 +/- 0.6 versus 8.2 +/- 2.2), collagen I-alpha 1 (5.6 +/- 2.0 versus 23.8 +/- 7.3), and collagen III (2.7 +/- 0.9 versus 7.6 +/- 2.1). Data were corrected for rpL32 mRNA expression and expressed relative to Wistar Kyoto (WKY) rats [=1.0]. Expression of fibronectin protein was also lowered by eprosartan (0.8 +/- 0.1 versus 1.9 +/- 0.5), relative to WKY rats. Eprosartan provided significant renoprotection to SHR-SP rats as measured by decreased proteinuria (22 +/- 2 versus 127 +/- 13 mg/day) and histological evidence of active renal damage (5 +/- 2 versus 195 +/- 6) and renal fibrosis (5.9 +/- 0.7 versus 16.4 +/- 1.9) in vehicle- versus eprosartan-treated rats, respectivel...Continue Reading

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Citations

Apr 12, 2003·Current Opinion in Pharmacology·Nicholas J Laping
Jan 10, 2008·Current Medical Research and Opinion·C Venkata S Ram
Jan 28, 2015·European Journal of Pharmacology·Mohamed A MorsyMagda E Mahmoud
Jan 25, 2013·International Journal of Molecular Sciences·Ryan C TurnerJason D Huber
Aug 11, 2004·The Journal of Pharmacology and Experimental Therapeutics·Luigi SironiElena Tremoli
Mar 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arashdeep SinghPrasanth K Chelikani
Apr 26, 2020·The Journal of Pharmacology and Experimental Therapeutics·Marie-Laure OzouxPhilip Janiak
May 5, 2021·Journal of Biochemical and Molecular Toxicology·Muhammad A E SaadMuhammad Al-Shorbagy

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