Abstract
Although "unmeasured" anions contribute to metabolic acidosis in a variety of disease states, they are generally not measured directly but estimated from the calculation of "gaps." Among the most commonly used method, the anion gap (AG) is not only a function of "unmeasured" anions, but also it is a function of plasma non-carbonate buffers (albumin and phosphate), the plasma pH, and the method of measurement. To clarify the contribution of non-carbonate buffers to the AG, the Figge-Fencl-Waston model of human plasma was applied to laboratory values obtained from two novel populations, patients with nephrotic syndrome and patients with diabetic ketoacidosis (DKA). The model performed adequately, justifying the common clinical practice of correcting the AG for the net protein charge.
References
Oct 13, 1977·The New England Journal of Medicine·M S Oh, H J Carroll
Dec 1, 1986·Journal of Applied Physiology·T H RossingV Fencl
Dec 1, 1983·Canadian Journal of Physiology and Pharmacology·P A Stewart
Jun 1, 1995·Journal of Critical Care·J A KellumM R Pinsky
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·N KauP Bartmann
Feb 1, 1996·Journal of the American Society of Nephrology : JASN·W D Paulson
May 7, 1998·Analytical Chemistry·M K Menon, A L Zydney
Jun 6, 1998·Journal of Applied Physiology·P Wilkes
Jul 22, 1998·Southern Medical Journal·R L JuradoJ L Pimentel
Nov 21, 1998·Critical Care Medicine·J FiggeV Fencl
Apr 8, 1999·Journal of Applied Physiology·P D Watson
Aug 25, 1999·Annals of Emergency Medicine·T M SchwabT C Soliz
Mar 31, 2000·Analytical Chemistry·E BakkerP Bühlmann
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·V FenclJ Figge
May 23, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·P H LolekhaS Lolekha
May 23, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·P H LolekhaU Chaichanajarernkul
Sep 5, 2001·Pediatrics·E I Felner, P C White
Aug 13, 2003·Kidney International·Howard E Corey
Jan 13, 2004·Analytical Biochemistry·Donald J Winzor
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Howard E Corey
Citations
Mar 6, 2007·Critical Care Medicine·Arnaldo DubinElisa Estenssoro
May 10, 2008·Critical Care : the Official Journal of the Critical Care Forum·Graciela TuhayArnaldo Dubin
Oct 9, 2014·The New England Journal of Medicine·Kenrick BerendRijk O B Gans
Sep 25, 2012·European Journal of Pediatrics·Jan HavlinMiroslava Horackova
Nov 3, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jianxin LuQing H Meng
Oct 18, 2015·Néphrologie & thérapeutique·Jan HavlinKarel Matousovic
Sep 3, 2014·Journal of Veterinary Emergency and Critical Care·Kate HopperMatthew S Mellema
Apr 2, 2014·TheScientificWorldJournal·Michalis AgrafiotisVassileios Michaelidis
Oct 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Horacio J Adrogué, Nicolaos E Madias
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey A Kraut, Nicolaos E Madias
Jun 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Asghar Rastegar
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Ira KurtzMinhtri K Nguyen
Sep 11, 2020·BioMed Research International·Tienan SunYujie Zhou