The Anrep effect: an intrinsic myocardial mechanism

Canadian Journal of Physiology and Pharmacology
C G NicholsB R Jewell

Abstract

In cat papillary muscles contracting physiologically, increasing the afterload caused a biphasic change in contractility. In response to an increase in afterload, contractility (as measured by peak shortening, peak developed force, or peak dF/dt) initially decreased (antihomeometric autoregulation) over the first few beats and then increased slowly with t 1/2 of about 3 min at 30 degrees C and about 1 min at 37 degrees C (homeometric autoregulation). The antihomeometric autoregulation is due to decreased active shortening when the afterload is increased, since it also occurs in response to increased afterload in isotonic contractions. The secondary slow increase in contractility is primarily due to the increase in mean diastolic length that occurs as a result of increased afterload. The time course and the magnitude of the biphasic change in contractility are very similar to those observed in response to afterload increase in intact hearts; we suggest that the secondary slow increase in contractility that we observed is a contributory mechanism to homeometric autoregulation (or the Anrep effect), as it is observed in the whole heart.

Citations

Apr 30, 2015·Seminars in Fetal & Neonatal Medicine·Anna Finnemore, Alan Groves
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J R FiorettoP J Tucci
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Pierre WauthySerge Brimioulle
Jul 24, 2010·Canadian Journal of Physiology and Pharmacology·Leonardo dos SantosPaulo J F Tucci
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Serge BrimioulleRobert Naeije
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dong-Feng YeihYung-Zu Tseng
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M de VroomenJ Baan
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P J TucciO Santana

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