The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue

Biological Trace Element Research
Xinyue WangJ Fu

Abstract

Selenium (Se) is a necessary trace mineral in the diet of humans and animals. Cadmium (Cd) is a toxic heavy metal that can damage animal organs, especially the kidneys. Antagonistic interactions between Se and Cd have been reported in previous studies. However, little is known about the effects of Se against Cd toxicity and on the mRNA levels of 25 selenoprotein genes and inflammatory factors in chicken kidneys. In the current study, we fed chickens with a Se-treated, Cd-treated, or Se/Cd treated diet for 90 days. We then analyzed the mRNA expression of inflammatory factors (including prostaglandin E synthase (PTGES), nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2)) and 25 selenoprotein genes (Gpx1, Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, SPS2, Sepp1, SelPb, Sep15, Selh, Seli, Selm, Selo, Sels, Sepx1, Selu, Selk, Selw, Seln, Selt). The results demonstrated that Cd exposure increased the Cd content in the chicken kidneys, renal tubular epithelial cells underwent denaturation and necrosis, and the tubules became narrow or disappeared. However, Se supplementation reduced the Cd content in chicken kidneys and induced normal development of renal tubular epithelial cel...Continue Reading

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Citations

Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
Feb 3, 2021·Antioxidants·Peter F SuraiMichael T Kidd
May 10, 2021·Environmental Pollution·Milton TalukderJin-Long Li
Aug 27, 2021·Biological Trace Element Research·Jia-Hong ChuRui-Feng Fan
Aug 29, 2021·Toxicology and Industrial Health·Mengyang LiZengli Zhang
Sep 12, 2020·Research in Veterinary Science·Jia-Hong ChuRui-Feng Fan

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Methods Mentioned

BETA
flame atomic absorption spectrometry
PCR
PCA

Software Mentioned

Statistics
Oligo Primer Analysis

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