The antagonistic MYB paralogs RH1 and RH2 govern anthocyanin leaf markings in Medicago truncatula.

The New Phytologist
Chongnan WangHao Lin

Abstract

Patterned leaf coloration in plants generates remarkable diversity in nature, but the underlying mechanisms remain largely unclear. Here, using Medicago truncatula leaf marking as a model, we show that the classic M. truncatula leaf anthocyanin spot trait depends on two R2R3 MYB paralogous regulators, RED HEART1 (RH1) and RH2. RH1 mainly functions as an anthocyanin biosynthesis activator that specifically determines leaf marking formation depending on its C-terminal activation motif. RH1 physically interacts with the M. truncatula bHLH protein MtTT8 and the WDR family member MtWD40-1, and this interaction facilitates RH1 function in leaf anthocyanin marking formation. RH2 has lost transcriptional activation activity, due to a divergent C-terminal domain, but retains the ability to interact with the same partners, MtTT8 and MtWD40-1, as RH1, thereby acting as a competitor in the regulatory complex and exerting opposite effects. Moreover, our results demonstrate that RH1 can activate its own expression and that RH2-mediated competition can repress RH1 expression. Our findings reveal the molecular mechanism of the antagonistic gene paralogs RH1 and RH2 in determining anthocyanin leaf markings in M. truncatula, providing a multidim...Continue Reading

References

Feb 1, 1997·Trends in Genetics : TIG·C Martin, J Paz-Ares
Jun 9, 2001·Journal of Theoretical Biology·S Lev-Yadun
Oct 13, 2001·Current Opinion in Plant Biology·R StrackeB Weisshaar
Nov 28, 2001·The Plant Journal : for Cell and Molecular Biology·A AharoniA P O'Connell
Jul 17, 2004·The Plant Journal : for Cell and Molecular Biology·Antoine BaudryLoïc Lepiniec
Feb 15, 2005·Trends in Plant Science·Nicola A Ramsay, Beverley J Glover
May 11, 2005·Trends in Plant Science·Ronald KoesFrancesca Quattrocchio
May 4, 2006·Annual Review of Plant Biology·Erich Grotewold
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen
Jan 23, 2008·The Plant Journal : for Cell and Molecular Biology·Million TadegeKirankumar S Mysore
Jun 6, 2008·The Plant Journal : for Cell and Molecular Biology·Christian DubosLoïc Lepiniec
Apr 17, 2009·The Plant Journal : for Cell and Molecular Biology·Gregory J PeelRichard A Dixon
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Oct 22, 2009·The Plant Journal : for Cell and Molecular Biology·Qing LuYuhai Cui
Jan 7, 2010·Nature Reviews. Genetics·Hideki Innan, Fyodor Kondrashov
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huanzhong WangRichard A Dixon
Mar 15, 2011·Nucleic Acids Research·Carol SoderlundWilliam M Nelson
Jul 19, 2011·Plant Science : an International Journal of Experimental Plant Biology·Katia Petroni, Chiara Tonelli
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hao LinMillion Tadege
Jun 19, 2013·Plant Physiology and Biochemistry : PPB·Giorgia CarlettiJamila Bernardi
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Oct 21, 2014·The New Phytologist·Nick W AlbertWarren M Williams
Jan 13, 2015·Trends in Plant Science·Wenjia XuLoïc Lepiniec
Mar 10, 2015·Nature Methods·Daehwan KimSteven L Salzberg
Feb 13, 2016·The Plant Cell·Meredith J Sigman, R Keith Slotkin
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cheng HuangFeng Tian
Jan 27, 2018·PLoS Computational Biology·Guillaume MarçaisAleksey Zimin
Nov 7, 2018·Nature Plants·Yann PecrixPascal Gamas
Nov 5, 2019·Molecular Plant·Chuanlong SunChuanyou Li

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