PMID: 412214Oct 20, 1977

The antagonizing effect of aspartic acid on the brain levels of monoamines and free amino acids during the development of tolerance to the physical dependence on morphine

H KoyuncuoğluH Sağduyu


Since it has been shown in previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study. The brain contents of serotonin, DA, NA, and free amino acids of the rats given aspartic acid and morphine separately and in combination were determined. It has been observed that most of the morphine-induced changes in the brain were normalized in the group given aspartic acid and morphine together. The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found.


Apr 29, 1977·Psychopharmacology·H KoyuncuoğluH Sağduyu
Jul 1, 1975·Headache·M A Pollack, J H French
Mar 1, 1969·European Journal of Pharmacology·L M GunneK Fuxe
Dec 1, 1968·The Journal of Pharmacy and Pharmacology·M J Neal
Jun 1, 1969·The Journal of Pharmacy and Pharmacology·E ContrerasL Quijada
Jan 3, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·H H LohE L Way
Jun 1, 1974·European Journal of Pharmacology·H KoyuncuoğluL Eroğlu
Mar 1, 1972·Biochemical Pharmacology·P J SchechterA Sjoerdsma
May 1, 1968·International Journal of Neuropharmacology·R P MaickelF P Miller
Apr 1, 1969·Biochimica Et Biophysica Acta·S Navon, A Lajtha
Dec 1, 1964·International Journal of Neuropharmacology·C C CHANG


Dec 20, 1979·European Journal of Pharmacology·H KoyuncuoğluE Genç
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·H Koyuncuoğlu, K Berkman
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluH Sabuncu
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Apr 29, 1977·Psychopharmacology·H KoyuncuoğluH Sağduyu
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H KoyuncuoğluI Kara
Jul 1, 1999·Addiction Biology·L TampierJ Mardones

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Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
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