PMID: 108753Mar 29, 1979

The antagonizing effect of aspartic acid on morphine withdrawal and levallorphan-precipitated abstinence syndrome signs and on associated changes in brain levels of free amino acids in the rat

H KoyuncuoğluH Sağduyu


We have previously demonstrated the antagonizing effect of aspartic acid on some effects of morphine and on the development of physical dependence on, and tolerance to, morphine. In the present study, we have withdrawal from morphine or administration of a morphine antagonist. For this purpose sixty five white rats were given morphine and aspartic acid separately and in combination in a 5% saccharose solution instead of drinking water for 30 days. Some of the dependent rats were then withdrawn and others were injected with levallorphan. Flying, jumping, wet-dog shaking, body weight loss and motor activity were estimated and free amino acid levels in the brain were determined. Aspartic acid was found to prevent or antagonize the behavioural signs and the changes in the free amino acid levels in the brain. The results are discussed in the light of the previous data.


Oct 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·G CampistronG Prat
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluH Sabuncu
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Jun 28, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y TadaD Nakae
Jan 15, 1986·Experientia·D S Minors, J M Waterhouse

Related Concepts

Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
Brain Chemistry
Withdrawal Symptoms
Rats, Laboratory

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