The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys

PLoS Biology
Benjamin M BasileElisabeth A Murray

Abstract

A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither monkey. Here, we assessed whether the ACC's contribution to social cognition is causal by testing rhesus monkeys (Macaca mulatta) on a vicarious reinforcement task before and after they sustained ACC lesions. Prior to surgery, actors learned that 3 different visual cues mapped onto 3 distinct reward outcomes: to self ("Self"), to the other monkey ("Other"), or to neither monkey ("Neither"). On each trial, actors saw a cue that predicted one of the 3 juice offers and could accept the offer by making a saccade to a peripheral target or reject the offer by breaking fixation. Preoperatively, all 6 actors displayed prosocial preferences, indicated by their greater tendency to give reward to Other relative to Neither. Half then received selective, bilateral, excitotoxic lesions of the ACC, and the other half served as unoperated controls. After surgery, all monkeys retained the social preferences they had demonstrated w...Continue Reading

References

Sep 4, 2001·Hippocampus·L MálkováR C Saunders
Dec 7, 2002·Journal of Neuroscience Methods·Sarah NemanicJocelyne Bachevalier
Mar 31, 2005·Current Biology : CB·Robert O DeanerMichael L Platt
Jul 9, 2005·Trends in Cognitive Sciences·John M AllmanAtiya Y Hakeem
Sep 2, 2006·Science·P H RudebeckM F S Rushworth
May 25, 2007·Journal of Neurophysiology·Daniel L AdamsJonathan C Horton
Oct 12, 2007·The European Journal of Neuroscience·Peter H RudebeckDavid M Bannerman
Feb 20, 2008·Psychophysiology·Margaret M BradleyPeter J Lang
Jun 14, 2008·Brain : a Journal of Neurology·Katharine N ThakkarDara S Manoach
Jun 17, 2010·The European Journal of Neuroscience·M P NoonanM F Rushworth
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heinrich S GompfJun Lu
Apr 26, 2011·Frontiers in Neuroscience·Steve W C ChangMichael L Platt
Aug 13, 2011·Nature·Janet C Garber
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca M JonesB J Casey
Nov 5, 2011·Science·J SalletM F S Rushworth
Dec 25, 2012·Nature Neuroscience·Steve W C ChangMichael L Platt
Jan 7, 2014·Frontiers in Neuroscience·Matthew A J AppsJoshua H Balsters
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jan Willem de GeeTobias H Donner
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peter H RudebeckElisabeth A Murray
May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew A J Apps, Narender Ramnani
Aug 28, 2014·PloS One·Olivia E KangThalia P Wheatley
Oct 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricia L LockwoodEssi Viding
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sebastien Ballesta, Jean-René Duhamel
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Katherine A Cronin
Jun 23, 2016·Neuroscience·Jenne M Westberry, Michael Meredith
Sep 7, 2016·Nature Communications·Michael R HillItzhak Fried
Dec 30, 2016·Brain : a Journal of Neurology·Joshua H BalstersNicole Wenderoth
Jun 24, 2017·Frontiers in Integrative Neuroscience·Benjamin M BasileElisabeth A Murray
Jul 5, 2018·Animal Cognition·Tyler Cash-PadgettBenjamin Y Hayden
Jul 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jessica TaubertLeslie G Ungerleider
Sep 19, 2018·Nature Neuroscience·Atsushi NoritakeMasaki Isoda
Nov 14, 2018·Nature Communications·Patricia L LockwoodMatthew F S Rushworth
Apr 16, 2019·Current Biology : CB·Maria CarrilloChristian Keysers
Jun 11, 2019·Journal of Healthcare Engineering·Jian Kang WuHong Jiang

❮ Previous
Next ❯

Citations

Nov 11, 2020·Nature Neuroscience·Prabaha GangopadhyaySteve W C Chang
Jan 12, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jérôme SalletMatthew Rushworth
Feb 11, 2021·Current Opinion in Neurobiology·Camille TestardMichael Platt
Feb 14, 2021·Neuroscience and Biobehavioral Reviews·Nicole C FerraraJ Amiel Rosenkranz
Mar 24, 2021·Current Opinion in Neurobiology·Enrica ParadisoChristian Keysers
Jun 4, 2021·The American Journal of Psychiatry·Daniel S PineElisabeth A Murray
Jul 15, 2021·IScience·Siqi FanSteve W C Chang
Aug 21, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yoonseo ZohMolly J Crockett
Aug 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elisabeth A Murray, Lesley K Fellows
Aug 29, 2021·Proceedings of the National Academy of Sciences of the United States of America·Atsushi FujimotoPeter H Rudebeck
Aug 2, 2020·Trends in Cognitive Sciences·Patricia L LockwoodSteve W C Chang

❮ Previous
Next ❯

Software Mentioned

MatLab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Tor D WagerTal Yarkoni
Current Oncology Reports
Sina Jasim, Mouhammed Amir Habra
© 2022 Meta ULC. All rights reserved