The anterior scalene muscle in thoracic outlet compression syndrome. Histochemical and morphometric studies

Archives of Surgery
H I MachlederM A Verity

Abstract

Histochemical studies and morphometric fiber type analysis were done on biopsy specimens of anterior scalene muscle (ASM) from patients with thoracic outlet compression syndrome (TOS), without structural abnormality. Hypertrophy and atrophy factors were determined from muscle fiber histograms of ASM from controls, patients with TOS, and after scalene tenotomy. Scalene muscle from patients with TOS showed marked type 1 (tonic contracting) fiber predominance (85.1% +/- 5.1%) and type 1 fiber hypertrophy (55.6 +/- 2.7 microns). After tenotomy there is a reduction of type 1 fiber representation, selective atrophy in the type 1 fiber system (atrophy factor, 0.66 +/- 0.24), and increase of type 2 fibers. These distinctive changes indicate that ASM is uniquely structured in fiber composition to sustain prolonged contraction. The ASM in patients with TOS demonstrates an extraordinary adaptive transformation and recruitment response in the type 1 fiber system reflecting chronic increased tone or motor neuron stimulation. These observations form a basis for clarifying the structural and pathophysiologic changes in TOS.

Citations

Nov 1, 1994·Postgraduate Medical Journal·J D UrschelR P Grewal
Jan 5, 2011·Journal of Occupational Rehabilitation·Jacky LaulanAlexis Descatha
Mar 6, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Paul J ChristoJulie A Freischlag
Feb 1, 1989·Journal of Vascular Surgery·W J McCarthyJ R Suker
Feb 1, 1993·American Journal of Surgery·R A KennyD J Keegan
Jul 5, 2011·Annals of Vascular Surgery·Hugh A GelabertDavid A Rigberg
Dec 1, 1987·American Journal of Surgery·D B Roos
Aug 2, 2003·Vascular and Endovascular Surgery·Wladislaw Ellis, Stephen Cheng
Jan 16, 2014·Hand : Official Journal of the American Association for Hand Surgery·Scott M Fried, Levon N Nazarian
Jan 1, 1991·American Journal of Industrial Medicine·A ToomingasS Kihlberg
Jul 21, 2006·Journal of Neurosurgery. Spine·Robert L Tiel, David G Kline
Nov 15, 2008·The Neurologist·Richard J SandersNeal M Rao
Jul 11, 2007·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Sedat Tolga AydoğMehmet Yörübulut
Sep 15, 2010·Current Opinion in Cardiology·Benjamin S Brooke, Julie A Freischlag
Jan 25, 2012·Acta neurochirurgica·Annie DubuissonDidier Martin
Jan 12, 1999·Muscle & Nerve·D B Roos
Jun 12, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Julie A Freischlag
Jan 1, 1988·Current Problems in Surgery·H Machleder
May 7, 1999·Clinics in Sports Medicine·A B Richardson
Sep 1, 1994·The Journal of Hand Surgery·S E Mackinnon, C B Novak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.