PMID: 11901088Mar 20, 2002Paper

The anthelminthic agent albendazole does not interact with p-glycoprotein

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Gracia MerinoRichard B Kim

Abstract

Albendazole is a clinically important anthelminthic agent known to have variable and low oral bioavailability. The aim of this work was to determine whether albendazole, a CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P-glycoprotein. Both in vitro and in vivo methods were used to assess the role of P-glycoprotein-mediated albendazole transport. In cultured LLC-PK1, L-MDR1, and Caco-2 cells, albendazole was found not to be a P-glycoprotein substrate; the transport across LLC-PK1 and L-MDR1 cells revealed basal to apical versus apical to basal transport to a similar extent. In addition, there was no inhibitory effect of albendazole on digoxin transport in Caco-2 cells, and P-glycoprotein inhibitors (verapamil and quinidine) did not affect transport across Caco-2 cells. The in vivo relevance of P-glycoprotein to albendazole disposition was assessed using mdr1a/1b(-/-) mice after intravenous administration of albendazole (15 mg/kg). A similar pattern of tissue distribution in both P-glycoprotein-deficient and wild-type mice was observed. In conclusion, albendazole is neither a substrate nor an inhibitor of P-glycoprotein. Therefore, interactions between albendazole and P-glycoprotein substrates or inhib...Continue Reading

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Citations

Mar 27, 2007·Pharmaceutical Research·Chong-Hui GuRonald L Smith
Sep 5, 2003·International Journal of Pharmaceutics·Gracia MerinoAna I Alvarez
Oct 3, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gracia MerinoAna I Alvarez
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Oct 2, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·María Teresita Paz-MaldonadoGuadalupe Ortega-Pierres
Nov 16, 2010·Veterinary Parasitology·Hana BártíkováBarbora Szotáková
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Feb 11, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gracia MerinoAlfred H Schinkel
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Apr 12, 2021·Acta Parasitologica·Adriana Ángeles-ArvizuGloria León-Avila

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.