The anthelmintic drug mebendazole inhibits growth, migration and invasion in gastric cancer cell model

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Laine Celestino PintoRaquel Carvalho Montenegro

Abstract

The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from a primary gastric cancer tumor. Our data reveal that MBZ showed high cytotoxicity in vitro, displaying an IC50 of 0.39 μM and 1.25 μM in ACP-02 and ACP-03, respectively. The association between MBZ and 5-FU increased slightly the cytotoxicity when compared to MBZ and 5-FU alone. Furthermore, MBZ disrupted the microtubule structure of AGP-01 cells and inhibited significantly the invasion and migration of these cells. Activity of active MMP-2 significantly decreased at all tested concentration of MBZ compared to negative control. These results support the indication of MBZ in combination with chemotherapeutic agents as a possible adjuvant therapy for the management/treatment of patients with advanced gastric cancer since MBZ is a drug of low cost with acceptable safety profile and reduced toxicity to normal cells. However, clinical trials must be performed in o to evaluate its efficacy in gastric cancer patients.

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Citations

Apr 12, 2017·Acta Medica (Hradec Králové)·Kristýna ČáňováEmil Rudolf
Sep 9, 2020·Immune Network·Deok-Soo SonSamuel E Adunyah
Apr 24, 2019·BMC Research Notes·Kristin BlomRolf Larsson
Jul 4, 2020·Signal Transduction and Targeted Therapy·Zhe ZhangCanhua Huang
Jul 17, 2020·International Journal of Molecular Sciences·Federica LaudisiCarmine Stolfi
May 18, 2020·European Journal of Cell Biology·Vladimír ČermákJan Brábek

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