Abstract
Papaya latex has been demonstrated to be an efficacious anthelmintic against murine, porcine, ovine and canine nematode parasites, and even those infecting poultry, and it has some efficacy against rodent cestodes. The active ingredients of papaya latex are known to be cysteine proteinases (CPs). The experiments described in this paper indicate that CPs in papaya latex, and also those in pineapples, are highly efficacious against the equine cestode Anoplocephala perfoliata in vitro, by causing a significant reduction in motility leading to death of the worms. The susceptibility of A. perfoliata to damage by CPs was considerably greater than that of the rodent cestodes Hymenolepis diminuta and H. microstoma. Our results are the first to report anthelmintic efficacy of CPs against an economically important equine helminth. Moreover, they provide further evidence that the spectrum of activity of CPs is not restricted to nematodes and support the idea that these plant-derived enzymes can be developed into useful broad-spectrum anthelmintics.
References
Nov 1, 1990·Biological Chemistry Hoppe-Seyler·D J ButtleA J Barrett
Apr 5, 1985·Biochimica Et Biophysica Acta·S ZuckerA J Barrett
Jun 8, 1968·Nature·J DrenthB G Wolthers
Jan 1, 1982·The Biochemical Journal·A J BarrettK Hanada
Jan 1, 1980·Zeitschrift Für Parasitenkunde·B BeckerH Thomas
Dec 1, 1994·Journal of Helminthology·F SatrijaS He
Jun 4, 1998·Parasitology Research·J Schmidt
Jun 11, 1998·Equine Veterinary Journal·C J ProudmanA J Trees
May 14, 1999·Parasitology Today·C J Proudman, A J Trees
Jul 14, 1999·The American Journal of Tropical Medicine and Hygiene·M IsmailJ L Bennett
Aug 13, 1999·Zentralblatt für Veterinärmedizin. Reihe A·A Rodríguez-BertosA Meana
Oct 22, 2002·Veterinary Research·Ray M Kaplan
Jul 9, 2004·Veterinary Research·Jacqueline B MatthewsChristopher J Proudman
Sep 15, 2004·Trends in Parasitology·Ray M Kaplan
Feb 25, 2005·Parasitology·G StepekJ M Behnke
Feb 2, 2006·Parasitology·G StepekJ M Behnke
Oct 13, 2006·Parasitology·G StepekJ M Behnke
May 4, 2007·Parasitology·G StepekJ M Behnke
Jul 21, 2007·Parasitology·G StepekJ M Behnke
Nov 17, 2007·Journal of Helminthology·Gillian StepekJerzy M Behnke
Sep 3, 2008·Parasites & Vectors·Jerzy M BehnkeIan R Duce
Mar 17, 2011·Parasites & Vectors·David J ButtleIan R Duce
Sep 5, 2013·Parasitology·A M PhiriJ M B Behnke
Jan 28, 2014·Veterinary Parasitology·F MansurJ M Behnke
Jun 3, 2014·Parasites & Vectors·Bruno LeveckeJozef Vercruysse
Sep 17, 2014·Journal of Helminthology·F MansurJ M Behnke
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Jacqueline B Matthews