The Anti-Angiogenic Effects of Anti-Human Immunodeficiency Virus Drugs

Frontiers in Oncology
Giovanni Barillari

Abstract

The growth and metastasis of malignant tumors benefit from the formation of blood vessels within the tumor area. There, new vessels originate from angiogenesis (the sprouting of pre-existing neighboring vessels) and/or vasculogenesis (the mobilization of bone marrow-derived endothelial cell precursors which incorporate in tumor vasculature and then differentiate into mature endothelial cells). These events are induced by soluble molecules (the angiogenic factors) and modulated by endothelial cell interactions with the perivascular matrix. Given angiogenesis/vasculogenesis relevance to tumor progression, anti-angiogenic drugs are often employed to buttress surgery, chemotherapy or radiation therapy in the treatment of a wide variety of cancers. Most of the anti-angiogenic drugs have been developed to functionally impair the angiogenic vascular endothelial growth factor: however, this leaves other angiogenic factors unaffected, hence leading to drug resistance and escape. Other anti-angiogenic strategies have exploited classical inhibitors of enzymes remodeling the perivascular matrix. Disappointingly, these inhibitors have been found toxic and/or ineffective in clinical trials, even though they block angiogenesis in pre-clinical...Continue Reading

References

Feb 19, 2000·Antimicrobial Agents and Chemotherapy·X R Pan-ZhouV M Darley-Usmar
Aug 26, 2003·European Journal of Immunology·Kathryn T WhelanSarah L Rowland-Jones
Dec 10, 2003·Brain : a Journal of Neurology·G M LiuzziP Riccio
Jul 2, 2004·American Journal of Physiology. Cell Physiology·Ly Q Hong-BrownCharles H Lang
Nov 2, 2004·Nature Reviews. Cancer·Paolo MoniniBarbara Ensoli
Aug 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hong ChaiChangyi Chen
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anjaiah SrirangamDavid A Potter
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vincenzo EspositoAntonio Chirianni
Nov 30, 2006·Neoplasia : an International Journal for Oncology Research·Nabendu PoreAmit Maity
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Apr 27, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathryn AnastosJessica Justman
May 19, 2007·Cancer Research·Kyle C CuneoChristopher D Willey
Jun 15, 2007·Trends in Immunology·Isabelle PetitShahin Rafii
Feb 21, 2008·Cancer Biology & Therapy·John P PlastarasAnjali K Gupta
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Matteo LandriscinaElena Ranieri
Jul 3, 2010·Journal of Neuro-oncology·Mahlon D JohnsonWebster Pilcher
Aug 5, 2010·Journal of Neuro-oncology·Manmeet S AhluwaliaDavid M Peereboom
Apr 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jesper MelchjorsenMartin Tolstrup
Jun 30, 2011·Investigational New Drugs·Ansgar BrüningIoannis Mylonas

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts

Software Mentioned

BEVACIZUMAB
RAMUCIRUMAB
AFLIBERCEPT

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.