The anti-asthmatic drug pranlukast suppresses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva)

European Journal of Pharmacology
Nissar A DarmaniFanglong Dong

Abstract

The introduction of second generation serotonin 5-HT3receptor (5-HT3) antagonist palonosetron combined with long-acting substance P neurokinin NK1receptor (NK1) antagonists (e.g. netupitant) has substantially improved antiemetic therapy against early- and delayed-phases of emesis caused by highly emetogenic chemotherapeutics such as cisplatin. However, the improved efficacy comes at a cost that many patients cannot afford. We introduce a new class of antiemetic, the antiasthmatic leukotriene CysLT1 receptor antagonist pranlukast for the suppression of cisplatin-evoked vomiting. Pranlukast (10mg/kg) by itself significantly reduced the mean frequency of vomits (70%) and fully protected least shrews from vomiting (46%) during the delayed-phase of cisplatin (10mg/kg)-evoked vomiting. Although, pranlukast tended to substantially reduce both the mean frequency of vomits and the number of shrews vomiting during the early-phase, these reductions failed to attain significance. When combined with a first (tropisetron)- or a second (palonosetron)-generation 5-HT3receptor antagonist, pranlukast potentiated their antiemetic efficacy during both phases of vomiting. In addition, pranlukast by itself prevented several intracellular signal mark...Continue Reading

Citations

Feb 8, 2019·Canadian Journal of Physiology and Pharmacology·Kouichi Yamamoto, Atsushi Yamatodani
May 19, 2021·European Journal of Pharmacology·Hayder M Al-KuraishyGaber El-Saber Batiha
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani

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