PMID: 20654107Jul 27, 2010Paper

The anti-athetotic effects of heme-L-lysinate in a rabbit model of atherosclerosis

Zhonghua xin xue guan bing za zhi
Xiao-bing Wang, Wan-lin Wei

Abstract

To investigate the anti-atherotic effects of heme-L-lysinate in a rabbit model of atherosclerosis and related machanisms. Adult rabbits were treated with 1% cholesterol diet (chol group, n = 8) or 1% cholesterol diet plus heme-L-lysinate (9 mgxkg(-1)xd(-1), Heme group, n = 8) or 1% cholesterol diet plus isotonic Na chloride (Na chloride group, n = 8) for 10 weeks. Eight rabbits fed with normal diet served as normal control. Aortic carbon monoxide (CO) was quantified spectrophotometrically by the formation of carboxyhaemoglobin (HbCO). Aortic heme oxygenase-1 (HO-1) and HSP70 mRNA and protein expressions were detected by RT-PCR and immunohistochemical staining. Aortic CO production and HO-1 activity were significantly increased in chol group and Na chloride group compared those in normal control group (P < 0.01). Aortic plaque area was significantly reduced in heme group (26.6% +/- 9.2%) than that in chol group (42.3% +/- 8.7%, P < 0.01). Aortic HO-1 expression, CO production and HSP70 were significantly increased in heme group than those in chol group and Na chloride group (all P < 0.01). Heme-L-lysinate could attenuate atherosclerotic progression through upregulating HO-1 and HSP70 expression and increasing CO production in th...Continue Reading

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Annales de l'anesthésiologie française
J L Parrot
European Journal of Pharmacology
F KozmaA Nasjletti
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova
Iu R Sheĭkh-ZadeI L Cherednik
Current Opinion in Clinical Nutrition and Metabolic Care
Philippe DevosJean-Charles Preiser
© 2021 Meta ULC. All rights reserved