The Anti-Cancer Effects of Frondoside A

Marine Drugs
T E Adrian, Peter Collin

Abstract

Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumariafrondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities.

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Citations

Feb 23, 2020·Marine Drugs·Emmanuel AmpofoMatthias W Laschke
Mar 17, 2021·Critical Reviews in Food Science and Nutrition·Devina LobineMohamad Fawzi Mahomoodally
Oct 1, 2021·Drug Discovery Today·Diana Duarte, Nuno Vale
Nov 10, 2021·Critical Reviews in Food Science and Nutrition·Yifan ZhouBaojun Xu

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Methods Mentioned

BETA
xenografts
fluorescence-activated cell sorting
xenograft

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