The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis.

Infection and Immunity
Ashraf S IbrahimJohn E Edwards

Abstract

We have previously shown that vaccination with a vaccine based on the recombinant N-terminal domain of Als1p (rAls1p-N) protected BALB/c mice against disseminated infection caused by a single strain of Candida albicans (A. S. Ibrahim, B. J. Spellberg, V. Avenissian, Y. Fu, S. G. Filler, and J. E. Edwards, Jr., Infect. Immun. 73:999-1005, 2005, and B. J. Spellberg, A. S. Ibrahim, V. Avenissian, S. G. Filler, C. Myers, Y. Fu, and J. E. Edwards, Jr., Infect. Immun. 73:6191-6193, 2005). Here we show that the rAls1p-N vaccine also improves survival of outbred mice from disseminated candidiasis and that it is active against multiple virulent strains of C. albicans and non-C. albicans spp.

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Citations

Jan 29, 2008·The Lancet Infectious Diseases·Antonio Cassone
Oct 14, 2008·Expert Reviews in Molecular Medicine·Cristina Cunha Villar, Anna Dongari-Bagtzoglou
Aug 21, 2010·Nature Reviews. Drug Discovery·Luis Ostrosky-ZeichnerJohn H Rex
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Aug 16, 2015·Cytokine·Natasha Whibley, Sarah L Gaffen
Aug 6, 2011·Immunological Investigations·James Isami Ito
Jun 10, 2010·FEMS Microbiology Reviews·Frank L van de VeerdonkBart Jan Kullberg
Jan 7, 2015·Virulence·Xiao-juan WangYuan-ying Jiang
Jul 12, 2008·FEMS Microbiology Letters·Kerstin Nather, Carol A Munro
Jul 23, 2009·Expert Review of Anti-infective Therapy·M Anaul Kabir, Mohammad Asif Hussain
Aug 6, 2019·PLoS Pathogens·Shakti SinghAshraf S Ibrahim
May 15, 2018·Frontiers in Immunology·Gloria Hoi Wan TsoNorman Pavelka
Jul 17, 2020·Expert Review of Anti-infective Therapy·Mubashshir RasheedRupinder Kaur
Apr 27, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John E EdwardsJohn P Hennessey
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sanam NamiHamid Morovati
May 18, 2017·Microbiology Spectrum·Neil A R GowCarol A Munro
Nov 20, 2021·International Journal of Antimicrobial Agents·Chibuike IbeOmran Alamir

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