Abstract
1. The selective NK1 receptor antagonist, CP-99,994, produced dose-related (0.1-1.0 mg kg-1, s.c.) inhibition of vomiting and retching in ferrets challenged with central (loperamide and apomorphine), peripheral (CuSO4) and mixed central and peripheral (ipecac, cisplatin) emetic stimuli. 2. Parallel studies with the enantiomer, CP-100,263 (1 mg kg-1, s.c.), which is > 1,000 fold less potent as a NK1 antagonist, indicated that it was without significant effect against CuSO4, loperamide, cisplatin and apomorphine-induced emesis. Against ipecac, it inhibited both retching and vomiting, expressing approximately 1/10th the potency of CP-99,994. 3. The 5-HT3 receptor antagonist, tropisetron (1 mg kg-1, s.c.) inhibited retching and vomiting to cisplatin and ipecac, but not CuSO4 or loperamide. 4. CP-99,994 (1 mg kg-1, i.v.) blocked retching induced by electrical stimulation of the ventral abdominal vagus without affecting the cardiovascular response, the apnoeic response to central vagal stimulation or the guarding and hypertensive response to stimulation of the greater splanchnic nerves. CP-99,994 (1 mg kg-1, i.v.) did not alter baseline cardiovascular and respiratory parameters and it failed to block the characteristic heart rate, bl...Continue Reading
References
May 1, 1992·British Journal of Pharmacology·S DiamantD Atlas
May 1, 1992·British Journal of Pharmacology·P I ThompsonM L Slevin
Aug 1, 1992·Neuropharmacology·P BhandariP L Andrews
Jun 1, 1992·Japanese Journal of Pharmacology·H FukuiS Sato
Oct 1, 1991·Neuropharmacology·N M BarnesJ A Rudd
Nov 12, 1991·European Journal of Pharmacology·P Bhandari, P L Andrews
Nov 29, 1991·Brain Research·D J ReynoldsR A Leslie
Jan 25, 1991·Science·R M SniderR W Spencer
Oct 1, 1991·Drugs·M S Aapro
Jan 1, 1991·Drug Design and Delivery·M B Tyers
May 1, 1990·Neuropharmacology·B CostallF D Tattersall
Feb 1, 1990·Canadian Journal of Physiology and Pharmacology·P L AndrewsL Maskell
Nov 1, 1990·Journal of the Autonomic Nervous System·S MilanoA L Bianchi
Feb 1, 1989·British Journal of Clinical Pharmacology·J R StottC J Ruddock
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·J B Lucot, G H Crampton
Jan 1, 1989·British Journal of Clinical Pharmacology·P J BaconS E Smith
Apr 1, 1985·The Journal of Comparative Neurology·B W NewtonH Traurig
May 1, 1989·British Journal of Pharmacology·G A HigginsM B Tyers
Nov 1, 1988·British Journal of Cancer·J BermudezG J Sanger
Jan 1, 1989·Journal of Reproduction and Fertility·M B Parr, E L Parr
Sep 1, 1988·Trends in Pharmacological Sciences·P L AndrewsG J Sanger
Jul 1, 1987·Neuropharmacology·B CostallD Tattersall
Sep 1, 1987·International Journal of Radiation Oncology, Biology, Physics·R E CordtsK A Hardy
Jul 1, 1986·British Journal of Pharmacology·W D Miner, G J Sanger
Aug 1, 1986·Neuropharmacology·B CostallF D Tattersall
Jan 1, 1986·Progress in Brain Research·G J Dockray, K A Sharkey
Jun 1, 1983·Cellular and Molecular Neurobiology·D O CarpenterN Strominger
Mar 1, 1981·The Journal of Comparative Neurology·D M ArmstrongR J Miller
Jul 8, 1982·Brain Research·D M ArmstrongD J Reis
Jan 13, 1980·Brain Research·R A GillisD M Jacobowitz
Mar 1, 1984·Behavioural Brain Research·D O CarpenterN Strominger
Jan 1, 1994·Brain Research Bulletin·N L StromingerD O Carpenter
Nov 2, 1993·European Journal of Pharmacology·C BountraP Ward
Sep 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P J Hesketh
Feb 1, 1994·Neuropharmacology·F D TattersallR J Hargreaves
Nov 30, 1993·European Journal of Pharmacology·F D TattersallR G Hill
Aug 1, 1993·Neuropharmacology·P L Andrews, P Bhandari
Jan 1, 1993·Brain Research Bulletin·A P KnoxD O Carpenter
Jan 1, 1985·Neurochemistry International·R A Leslie
Citations
May 29, 2010·Cancer Chemotherapy and Pharmacology·N Percie du SertP L R Andrews
May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Sep 13, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jarmo HietalaOlof Solin
May 2, 2009·Archives of Pharmacal Research·Qiu-Hai QianWen-Hui Chen
Jun 3, 1996·European Journal of Pharmacology·S GonsalvesC Ashton
Jul 4, 1996·European Journal of Pharmacology·P AndrewsN Matsuki
Aug 27, 1996·Regulatory Peptides·C J GardnerP Ward
Sep 28, 1998·Brain Research·H FukudaY Shiroshita
Oct 25, 2001·European Journal of Pharmacology·M MinamiP L Andrews
Dec 4, 2001·European Journal of Pharmacology·T YoshikawaM Oka
Feb 15, 2003·European Journal of Pharmacology·Sachiko TanihataToshimitsu Uchiyama
Feb 26, 1997·European Journal of Pharmacology·L SinghR J Naylor
Feb 24, 1998·European Journal of Pharmacology·Y ShiroshitaH Fukuda
May 20, 1997·European Journal of Pharmacology·N M RupniakR J Hargreaves
Jan 7, 1999·European Journal of Pharmacology·M MinamiK Kisara
Mar 19, 1999·European Journal of Pharmacology·J A RuddM K Wai
Aug 12, 1999·European Journal of Pharmacology·A Saria
Jul 28, 1999·European Journal of Pharmacology·J A RuddM K Wai
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Farideh A Javid, Robert J Naylor
Jul 31, 2003·Pharmacology & Therapeutics·Masaru MinamiMitsuhiro Yoshioka
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Dec 24, 1997·Journal of the Autonomic Nervous System·E R Partosoedarso, L A Blackshaw
Aug 8, 1998·Journal of the Autonomic Nervous System·J W ButcherJ F Paton
Mar 30, 1999·Neuroscience Research·H FukudaY Shiroshita
Nov 25, 2000·Toxicology·T EndoS H Parvez
May 29, 2000·Neuroscience Letters·H AriumiH Kamiya
Nov 8, 2001·Neuroscience Letters·P L AndrewsJ W Watson
Apr 24, 1999·Neuroscience Letters·R SaitoH Kamiya
Nov 3, 2005·Nature Clinical Practice. Oncology·Thein H Oo, Paul J Hesketh
Jan 1, 1997·British Journal of Pharmacology·J B LucotJ W Watson
Dec 24, 1997·British Journal of Pharmacology·K A Maubach, R S Jones
Oct 2, 1998·British Journal of Pharmacology·L GrélotP Ward
Jul 25, 2000·British Journal of Pharmacology·P L AndrewsN Matsuki
Sep 28, 1998·The European Journal of Neuroscience·J F Paton
Jun 4, 1997·Journal of the National Cancer Institute·M G KrisP J Hesketh
Jul 11, 2000·Current Opinion in Oncology·H Bleiberg
Nov 16, 2005·Behavioural Pharmacology·Angie H Y LauDavid T W Yew
Dec 1, 1995·British Journal of Pharmacology·C J GardnerP Ward
Mar 1, 1996·British Journal of Pharmacology·J L MontastrucP Montastruc
Nov 1, 1996·British Journal of Pharmacology·J A RuddR J Naylor
Mar 18, 2000·Infection and Immunity·A WrightR W Titball
Aug 24, 1999·Gut·J D WoodP L Andrews
Jan 28, 2005·The American Journal of Chinese Medicine·Sangeeta R MehendaleChun-Su Yuan
Jan 28, 2014·PloS One·Carey D BalabanBill J Yates
Mar 26, 2009·Magyar onkologia·Béla Pikó, Ali Bassam
Oct 13, 2000·Drugs·P Diemunsch, L Grélot
Oct 26, 2013·European Journal of Pharmacology·Howard S Smith, Andras Laufer
Apr 15, 2014·Neuropharmacology·Sze Wa ChanJohn A Rudd
May 28, 2014·Experimental Brain Research·Charles C Horn
Apr 17, 2014·Experimental Brain Research·Bill J YatesAndrew A McCall