The anti-inflammatory and anti-oxidative actions of eugenol improve lipopolysaccharide-induced lung injury

Respiratory Physiology & Neurobiology
Clarissa B MagalhãesWalter A Zin

Abstract

Acute lung injury (ALI) remains a major cause of mortality. In lipopolysaccharide (LPS)-stimulated macrophages, eugenol reduces cyclooxygenase-2 expression, NF-κB activation, and inflammatory mediators. We examined the anti-inflammatory and anti-oxidative action of eugenol in an in vivo model of LPS-induced lung injury. Lung mechanics and histology were analyzed in mice 24 h after LPS exposure, with and without eugenol treatment at different doses. Additional animals, submited to the same protocol, were treated with eugenol at 150 mg/kg to determine its effect on inflammatory cytokines (ELISA) and oxidative markers. LPS-induced lung functional and histological changes were significantly improved by eugenol, in a dose-dependent way. Furthermore, eugenol (150 mg/kg) was able to inhibit the release of inflammatory cytokines (TNF-α, IL-1β and IL-6), NADPH oxidase activity, as well as antioxidant enzymes activity (superoxide dismutase, catalase and glutathione peroxidase). Finally, eugenol reduced LPS-induced protein oxidation. In conclusion, eugenol improved in vivo LPS-induced ALI through both anti-inflammatory and anti-oxidative effects, avoiding damage to lung structure.

Citations

May 23, 2019·Respiratory Research·Saeideh SaadatMohammad Hossein Boskabady
Aug 7, 2020·Biomolecules·Georg SandnerJulian Weghuber
Jan 10, 2019·Journal of Biomedical Science·Jonatas Rafael de OliveiraLuciane Dias de Oliveira
Dec 16, 2020·Biochimica Et Biophysica Acta. General Subjects·Kesley A O PontesAna Acacia S Pinheiro
Dec 11, 2020·Environmental Pollution·Felipe Gomes PinheiroWalter Araujo Zin
Mar 23, 2021·Oxidative Medicine and Cellular Longevity·Oana M AburelLaura C Rusu
Jul 15, 2021·BioMed Research International·Wen-Ying YuChen-Huan Yu
Aug 24, 2021·Free Radical Research·Nayanne Hardy Lima PontesRodrigo Maranguape Silva da Cunha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here