Abstract
Diabetic nephropathy is a serious complication of diabetes whose development process is associated with inflammation, renal hypertrophy, and fibrosis. Coreopsis tinctoria Nutt, traditionally used as a healthcare tea, has anti-inflammatory, anti-hyperlipidemia, and glycemic regulation activities. The aim of our study was to investigate the renal protective effect of ethyl acetate extract of C. tinctoria Nutt (AC) on high-glucose-fat diet and streptozotocin (STZ)-induced diabetic rats. A diabetic rat model was induced by high-glucose-fat diet and intraperitoneal injection of 35 mg/kg STZ. After treatment with AC at a daily dose of 150, 300 or, 600 mg/kg for 4 weeks, metabolic and renal function parameters of serum and urine were examined. Degree of renal damage, renal proinflammatory cytokines, and fibrotic protein expression were analyzed by histopathology and immunohistochemistry. Renal AMP-activated protein kinase (AMPK) and transforming growth factor (TGF)-β1/Smad signaling pathway were determined by western blotting. Diabetic rats showed obvious renal dysfunction, inflammation and fibrosis. However, AC significantly reduced levels of blood glucose, total cholesterol, triglyceride, blood urea nitrogen, serum creatinine and ur...Continue Reading
References
Dec 8, 1989·European Journal of Biochemistry·S P DaviesD G Hardie
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F N Ziyadeh
Nov 1, 1996·The Journal of Biological Chemistry·S A HawleyD G Hardie
Dec 31, 2002·Journal of Diabetes and Its Complications·Tsukasa MoriiSeiki Ito
Jan 28, 2003·Biochemical Society Transactions·B E KempL A Witters
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Roger M Mason, Nadia Abdel Wahab
Nov 25, 2003·Seminars in Nephrology·Sheldon ChenFuad N Ziyadeh
Jun 3, 2005·American Journal of Physiology. Cell Physiology·Jingfei ChengJoseph P Grande
Oct 5, 2006·American Journal of Physiology. Renal Physiology·Myung-Ja LeeBalakuntalam S Kasinath
Feb 6, 2008·The Journal of Biological Chemistry·Rangnath MishraMichael S Simonson
Feb 15, 2008·American Journal of Physiology. Renal Physiology·G H Tesch
Feb 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hyun Woo JeongJae Bum Kim
May 1, 2009·Nature Reviews. Drug Discovery·Nigel A CalcuttAnn Marie Schmidt
Feb 26, 2010·American Journal of Physiology. Renal Physiology·Kenneth R HallowsDavid A Power
Sep 4, 2010·Journal of Ethnopharmacology·Teresa DiasAlexandra Paulo
Jun 11, 2011·Contributions to Nephrology·Hui Yao Lan, Arthur C K Chung
Sep 17, 2011·Journal of the American Society of Nephrology : JASN·Anne-Emilie DeclèvesKumar Sharma
Sep 20, 2011·International Journal of Biological Sciences·Hui Yao Lan
Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·Hui Yao Lan
Jul 25, 2012·Nature Reviews. Endocrinology·Mark E Cooper
Oct 19, 2012·Clinical Science·Jun Wada, Hirofumi Makino
Oct 30, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S O KolsetT Jenssen
Nov 6, 2012·The New England Journal of Medicine·Hans-Henrik ParvingUNKNOWN ALTITUDE Investigators
Feb 8, 2013·Frontiers in Endocrinology·Keizo KanasakiDaisuke Koya
Feb 26, 2013·European Journal of Medical Research·Li ZhuoWenwen Ren
Apr 9, 2013·Fitoterapia·Yuan ZhangPengfei Tu
May 15, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xing-Xin XuJi-Jia Shen
Mar 22, 2014·International Journal of Endocrinology·Vivian SoetiknoRianto Setiabudy
Mar 29, 2014·BMC Complementary and Alternative Medicine·Hung-Jen LuI-Min Liu
Aug 16, 2014·World Journal of Diabetes·Patricia M García-GarcíaJuan F Navarro-González
Oct 25, 2014·International Journal of Nephrology and Renovascular Disease·Andy Kh Lim
Nov 21, 2014·Journal of Diabetes Investigation·Xiaoping Chen, Wenying Yang
Nov 28, 2014·American Journal of Physiology. Renal Physiology·Jinghong ZhaoKumar Sharma
Dec 17, 2014·Lipids in Health and Disease·Yali LiMuhuyati Wulasihan
Dec 18, 2014·Journal of Agricultural and Food Chemistry·Wei WangZhihong Xin
Mar 13, 2015·Der Internist·S WerthJ Steinhoff
Citations
Apr 6, 2016·Journal of Ethnopharmacology·Jian WangXinmin Mao
Oct 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yinjun YangBaolin Guo
Jan 9, 2017·Cytokine·Changlu Liu, Dianming Jiang
Jul 14, 2020·Archives of Physiology and Biochemistry·Lei WangJianwen Wang
Jul 7, 2017·Electrophoresis·Yong DengShao-Ping Li
Jan 12, 2019·BMC Complementary and Alternative Medicine·Lan YaoXinmin Mao
Jan 18, 2020·Scientific Reports·Nan-Nan ZhangXin-Min Mao
Apr 30, 2019·BioMed Research International·Shunjie YuYi Jiao
Jul 21, 2020·American Journal of Physiology. Renal Physiology·Hong SunXiong Z Ruan
Nov 30, 2018·Mini Reviews in Medicinal Chemistry·Flavio FranciniJosé-Luis Ríos
Jun 10, 2020·Plants·Bo-Ram KimAh-Reum Han
Jan 8, 2020·International Journal of Molecular Sciences·Shara Francesca RapaStefania Marzocco
Dec 15, 2020·Journal of Ethnopharmacology·Jie ShenPeigen Xiao
Feb 3, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qian YuChunyan Yan
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yanli GuoXinmin Mao
Jun 3, 2021·Biomolecules·Liang-Jun Yan