Abstract
To investigate the anti-inflammatory effect of topical application of Curcuma longa (C. longa) and Berberis aristata (B. aristata) aqueous extracts on experimental uveitis in the rabbit. Anterior uveitis was induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. longa and B. aristata aqueous extracts. Subsequently, the anti-inflammatory activity of C. longa and B. aristata was evaluated by grading the clinical signs and histopathologic changes and estimating the inflammatory cell count, protein, and TNF-alpha levels in the aqueous humor. The anterior segment inflammation in the control group was significantly higher than in both the extract-treated groups, as observed by clinical and histopathologic grading. The inflammatory cell count in the control group was 30.75 +/- 7.33 x 10(5) cells/mL, whereas it was 2.39 +/- 0.59 x 10(5) (P < 0.001 vs. control) and 11.56 +/- 2.44 x 10(5) (P = 0.001 vs. control) cells/mL in the C. longa- and B. aristata-treated groups, respectively. The protein content of the aqueous humor was 18.14 +/- 4.98, 3.16 +/- 0.55 (P < 0.001 vs. control), and 8.24 +/- 1.42 (P < 0.01 vs. control) mg/mL in the control, C. longa-, and B. aristata-treated ...Continue Reading
Citations
Feb 1, 2009·Expert Opinion on Drug Discovery·Renu AgarwalShyam Sunder Agrawal
Jul 19, 2012·Fitoterapia·Dipti PotdarSivakami Dhulap
Apr 27, 2016·Indian Journal of Pharmacology·Rohit KumarSurender Singh
May 14, 2014·Journal of Cellular Biochemistry·Akshay AnandSushmita Kaushik
Jul 10, 2014·ISRN Pharmacology·Mohammed AzeemuddinRamakrishnan Shyam
Apr 11, 2015·Pharmaceutical Biology·Sanjeev ChandelDeepak Kumar Semwal
Apr 30, 2015·Bioscience, Biotechnology, and Biochemistry·Kengo KawasakiShinji Murosaki
Dec 12, 2012·Current Eye Research·Karthikeyan KesavanJayanta Kumar Pandit
Sep 29, 2011·Current Eye Research·Karthikeyan KesavanJayanta Kumar Pandit
Apr 7, 2015·Journal français d'ophtalmologie·P DurieuxS G Rosolen
May 28, 2016·Critical Reviews in Food Science and Nutrition·Wen SunXiuping Chen
Jun 14, 2016·Immunological Investigations·Rohit KumarS Arunraja
Aug 28, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Rasool ChoopaniMohammad Kamalinejad
Aug 28, 2018·Bioscience, Biotechnology, and Biochemistry·Kengo KawasakiYoshihiro Yamamoto
Nov 6, 2018·Cornea·Melih UstaogluFeyza Onder
Sep 13, 2019·AMB Express·Henna SoodDaljit Singh Arora
Dec 7, 2016·Molecular Medicine Reports·Yan YangZhuo Li
Mar 21, 2019·Pharmaceutical Development and Technology·Mitra Alami-MilaniMitra Jelvehgari
Dec 30, 2016·Future Science OA·Shirin FatehSaeed Daneshmandi
Mar 7, 2017·Frontiers in Pharmacology·Xiu-Fen LiuDan-Dan Zhou
Aug 21, 2012·Toxicology and Industrial Health·Tamer SagirogluMustafa Erboga
Apr 18, 2018·Bioscience of Microbiota, Food and Health·Kengo KawasakiShinji Murosaki
Jul 30, 2019·International Journal of Pharmaceutics·Aws AlshamsanAfsaneh Lavasanifar
Mar 17, 2021·Experimental Eye Research·Laxmi MokshaThirumurthy Velpandian
May 18, 2021·Journal of Ethnopharmacology·Arun Kumar KhajuriaN S Bisht
Nov 11, 2021·Journal of the American College of Nutrition·Jasleen BhasinVikas Chopra