The anti-inflammatory effects of IV administered clenbuterol in horses with recurrent airway obstruction

The Veterinary Journal
Tamarinde T J M LaanJ Fink-Gremmels

Abstract

Cyclic AMP elevating agents have been shown to exhibit anti-inflammatory properties in addition to functions such as bronchodilation. The aim of this study was to investigate this dual action of clenbuterol (CB; Ventipulmin) on horses affected with recurrent airway obstruction (RAO). Seven RAO susceptible horses received inhalation challenges with aerosolised lipopolysaccharide (LPS), hay dust suspension (HDS) and Aspergillus fumigatus antigen (AF) with and without prior treatment with intravenous CB. Data showed that CB exerted significant beneficial effects on lung function, total cell count (TCC) and bronchoalveolar lavage neutrophil influx. In addition, CB significantly decreased the expression of several pro-inflammatory cytokines and chemokines in the alveolar macrophages of RAO-susceptible horses after challenge with LPS and HDS, and increased the expression of interleukin-6, known to act as a pro-and anti-inflammatory cytokine, following different challenges. This anti-inflammatory activity of CB is of additive value to its currently recognised use in equine RAO.

References

Jan 1, 1995·Annual Review of Pharmacology and Toxicology·K S MaddenD L Felten
May 1, 1995·The British Veterinary Journal·N E RobinsonV A Buechner-Maxwell
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·C A IzeboudR F Witkamp
Oct 16, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C A IzeboudR F Witkamp
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·F BureauP Lekeux
Apr 18, 2000·Chest·S M Opal, V A DePalo
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·N AlexisD B Peden
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·J P LavoieQ A Hamid
Apr 24, 2002·Pulmonary Pharmacology & Therapeutics·Shelby P UmlandSebastian L Johnston
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R S PirieB C McGorum
Mar 17, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C A IzeboudR J T Rodenburg

❮ Previous
Next ❯

Citations

Dec 30, 2011·American Journal of Veterinary Research·Jennifer R ReadRose D Nolen-Walston
Nov 19, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alex ManiniLewis S Nelson
Jan 5, 2011·Veterinary Immunology and Immunopathology·Kristopher J HughesStephen P Dunham
Oct 18, 2008·The Veterinary Journal·Charles F Kearns, Kenneth H McKeever
Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Oct 30, 2013·Equine Veterinary Journal·R S Pirie
Mar 7, 2013·Research in Veterinary Science·L A CudmoreS R Bailey
Apr 25, 2015·American Journal of Veterinary Research·Rose D Nolen-WalstonLawrence R Soma
Jul 28, 2016·Journal of Veterinary Pharmacology and Therapeutics·A H Werners
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Oct 17, 2017·Frontiers in Veterinary Science·Emily Medlin MartinSamuel L Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.