The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism

Biogerontology
Dianni CapeletoIvana Beatrice Mânica da Cruz

Abstract

Resveratrol is an molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this compound. In humans, a single nucleotide polymorphism (SNP) is present in the enzyme manganese superoxide dismutase (SOD2), localized in codon 16 (rs4880), which can either be an alanine (A) or valine (V). This SNP causes an imbalance in the cellular levels of SOD2, where AA- and VV-genotypes result in higher or lower enzymatic activity, respectively. Furthermore, the VV-genotype has been associated with high levels of inflammatory cytokines. Here, we examined the effects of a range of resveratrol concentrations on the in vitro activation of human peripheral blood mononuclear cells (PBMCs) carrying different Ala16Val-SOD2 genotypes. Cell proliferation, several oxidative biomarkers and cytokines (IL-1β, IL-6, TNFα, Igγ and IL-10) were analyzed. In addition, the effects of resveratrol on the expression of the sirt1 gene were evaluated by qRT-PCR. After 24 h exposure to resveratrol, A-genotype PBMCs displayed a decrease in cell proliferation, whilst VV-cells contrasted; At 10 µM resveratrol, there was a significant decrease in the p...Continue Reading

References

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Citations

Aug 5, 2015·Biogerontology·Guillermo López-Lluch, Suresh I S Rattan
Mar 14, 2017·Rejuvenation Research·Fernanda BarbisanIvana Beatrice Mânica da Cruz
Dec 23, 2016·Environmental Science and Pollution Research International·Eduardo B DornellesIvana B M da Cruz
Jul 25, 2019·International Journal of Molecular Sciences·Donatella PastoreDavid Della-Morte
Jan 15, 2021·Experimental Gerontology·Camila Amaro CaldeiraMiriam Martins Chaves
Sep 24, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Karen Lilian SchottIvana Beatrice Mânica da Cruz

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