The anti-inflammatory secoiridoid glycosides from gentianae scabrae radix: the root and rhizome of Gentiana scabra

Journal of Natural Medicines
Yu-Min HeKatsuko Komatsu

Abstract

Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly of secoiridoid glycosides, with representatives of gentiopicroside, sweroside and swertiamarin. In the present study, a chemical investigation of the CHCl3 extract of Gentianae Scabrae Radix derived from Gentiana scabra Bunge yielded seven new (1-7) and ten known (8-17) secoiridoid glycosides. Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. All 17 compounds were evaluated for their inhibitory effects against NO, IL-6 and TNF-α productions induced by lipopolysaccharide (LPS) in RAW264 cells. Among them, 8-epi-kingiside derivatives 1-3; kingiside derivatives 4, 5 and 10; and a sweroside derivative 6 showed inhibition activity against IL-6 production with IC50 values of 51.70-61.10 μM, whereas sweroside derivatives 12 and 15-17 and a swertiamarin derivative 13 showed inhibition effects on both NO and IL-6 productions with IC50 values of 64.74-94.95 and 48.91-75.45 μM, respectively. All the compounds exhibited weak inhibitory activity (IC50 > 100 μM) in a TNF-α bioassay. Finally, a primary structure-activity rel...Continue Reading

References

Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Jul 1, 1996·Phytochemistry·R X TanK Hostettmann
Jan 5, 2002·Journal of Natural Products·R KakudaM Kikuchi
Apr 9, 2002·Phytochemistry·Rie KakudaMasao Kikuchi
Jun 1, 2005·Journal of Natural Products·Masao KikuchiYasunori Yaoita
Aug 1, 1990·Planta medica·I CalişO Sticher
Aug 1, 1997·Planta medica·H Q Tang, R X Tan
Apr 1, 1988·Planta medica·E Mpondo Mpondo, A J Chulia
Mar 23, 2007·Journal of Natural Products·Min XuChong-Ren Yang
Jul 1, 1983·Planta medica·Y Ikeshiro, Y Tomita
Jun 2, 2007·Chemical & Pharmaceutical Bulletin·Takashi TanakaIsao Kouno
May 13, 2008·Journal of Asian Natural Products Research·Min XuChong-Ren Yang
Jun 27, 2009·Archives of Pharmacal Research·Jeong-Ah KimSeung-Ho Lee
Jul 24, 2010·Journal of Natural Medicines·Kenzo ChibaMasao Kikuchi
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Mar 4, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S SaravananS Ignacimuthu

❮ Previous
Next ❯

Citations

Nov 19, 2015·International Journal of Molecular Sciences·Jian-Hong YeJing-Yu He
Sep 16, 2017·Journal of Food and Drug Analysis·Tun-Pin HsuehTung-Hu Tsai
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaole ZhangDe-An Guo
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Huailong BiJiefang Kang
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhaoxin ZhangWu Yin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.