The anti-ischemic effect of metoprolol in patients with chronic angina pectoris is gender-specific

Cardiology
Giuseppe Cocco, David Chu

Abstract

Several gender-specific differences in cardiovascular diseases are known and pharmacokinetics of beta-blockers shows relevant sex-specific differences. The plasma levels of metoprolol, for example, are higher in women compared to men. However, randomized studies have shown that metoprolol has little or no greater reduction in the mortality of women following myocardial infarction. We tested the hypothesis that metoprolol might have significant gender-specific effects in patients with chronic angina pectoris. Body weight of women was slightly (-9%) less than that of men and the daily dose of metoprolol was similar in both groups. Thus, according to pharmacokinetics women should have obtained higher plasma levels of this drug and the ensuing pharmacologic effects of metoprolol should have been greater. Our results do not confirm this assumption. Metoprolol reduced the frequency of angina episodes and the consumption of nitroglycerin tablets to a similar extent in both sexes. However, the pretreatment hemodynamic profiles confirmed the existence of gender-specific differences: women had significantly higher heart rate and blood pressure both at rest and during exercise. Since both groups were comparable in age, comorbidities, and ...Continue Reading

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Citations

Nov 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koichi Ueno, Hiromi Sato
Aug 1, 2015·Cardiovascular Drugs and Therapy·Amanda J Stolarz, Nancy J Rusch
Jul 25, 2012·International Journal of Cardiology·Cinzia ZuchiGiuseppe Ambrosio
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Apr 6, 2021·Mayo Clinic Proceedings·Matthias R Meyer
May 25, 2021·Frontiers in Cardiovascular Medicine·Marta FarreroBeatriz Díaz Molina

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