The anti-seizure effects of IV 5α-dihydroprogesterone on amygdala-kindled seizures in rats

Epilepsy Research
Yinhao Violet Wu, W M Burnham

Abstract

The present study investigated the anti-seizure effects of 5α-dihydroprogesterone (DHP) in an animal model of human drug-resistant focal seizures with impaired awareness. DHP was administered via the intravenous (IV) route. Female Wistar rats were implanted with an electrode in the right basolateral amygdala. They were then kindled to 15 stage 5 seizures, stability tested, and cannulated in the jugular vein. Multiple doses of IV DHP were tested against focal electrographic seizures and secondarily generalized convulsions. The time-course of DHP's action was also examined. The dose-response study, done at 5 min after injection, showed a dose-dependent suppression of both generalized and focal seizures, with an ED50 of 1.69 mg/kg for the generalized convulsive seizures and an ED50 of 3.48 mg/kg for the focal electrographic seizures. Ataxia, as rated by the Löscher ataxia scale, was also seen, with a TD50 of 3.57 mg/kg. The time-response study, done at the ED75 for focal seizure suppression, showed suppression of both generalized and focal seizures from immediately after injection to about 60 min post-injection. DHP has demonstrated anti-seizure effects in a drug-resistant model of human focal seizures with impaired awareness. Its...Continue Reading

Citations

Jul 31, 2020·Steroids·Carmen J Zamora-SánchezIgnacio Camacho-Arroyo
Oct 30, 2020·Frontiers in Endocrinology·Barbara MiziakStanisław J Czuczwar

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