PMID: 25788276Mar 20, 2015Paper

The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer

Oncotarget
Takanori GoiAkio Yamaguchi

Abstract

Hematogenous metastasis, mainly hepatic metastasis, is a frequent metastatic mode in colorectal cancer involving angiogenic growth factors. Two angiogenic growth factors, in particular, Vascular endothelial growth factor (VEGF) and Prokineticin1(PROK1), are considered to have an important role in hematogenous metastasis of colorectal cancer. Accordingly, we report our findings on the importance of the anti-tumor efffect by inhibiting these two factors in human colorectal cancer.When the culture fluid of Colorectal cancer cell lines(DLD-1, HCT116, and LoVo) with high levels of VEGF/PROK1 expression was injected subcutaneously into mice, the culture fluid increased subcutaneous angiogenesis. But when both anti-PROK1 and anti-VEGF antibodies were present in the culture fluid, the length and size of the blood vessels were reduced compared with those seen in the fluid-only, anti-PROK1, and anti-VEGF controls. Also, tumor masses were produced in mice by subcutaneously embedding colorectal cancer cells with high levels VEGF/PROK1 expression. When both anti-PROK1 and anti-VEGF antibodies were simultaneously applied, tumor formation and peritumoral angiogenesis were strongly suppressed, compared with when either anti-PROK1 antibody or a...Continue Reading

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Citations

May 12, 2016·Experimental and Therapeutic Medicine·Ying Chen, Xianfei Hong
Apr 8, 2017·International Journal of Endocrinology·Ana Silvia CorlanMarius Raica
Feb 13, 2020·International Journal of Molecular Sciences·Kiyoharu FukushimaHiroshi Kida

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