The Antibacterial Activity of Hydroxyapatite-Tryptophan Complex with Gray Titania by Photocatalysis Using LED Diodes

The International Journal of Oral & Maxillofacial Implants
Kanda LeelanarathiwatFumihiko Watanabe

Abstract

Peri-implantitis is an important biologic complication that can lead to implant failure. Proper treatment should effectively kill bacteria, not harm the implant surface, and promote regeneration. Recently, photocatalytic coating without antibiotics or external agents was proposed to be an alternative to antibiotic therapy. The aim of this study was to evaluate the photocatalytic antibacterial effect of a new titanium implant coating made from hydroxyapatite-tryptophan complex and gray titania, which was activated by two visible lights. Titanium alloy substrate was plasma sprayed with hydroxyapatite (80 wt%) and dititanium trioxide (20 wt%) and then pressed with tryptophan. Three bacteria related to peri-implantitis, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, were used in this study. Six conditions were tested: (1) control group (only bacteria), (2) photocatalytic sample in darkness (bacteria and coated sample in darkness), (3) red laser for 15 minutes (bacteria irradiated with photoactivated disinfection [PAD] light, 650-nm wavelength), (4) broadband light-emitting diode (LED) for 15 minutes (bacteria irradiated with broadband LED, peak wavelength at 470 nm), (5) photocatalysis by...Continue Reading

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