The antibacterial effect of fatty acids on Helicobacter pylori infection

The Korean Journal of Internal Medicine
Sung Woo Jung, Sang Woo Lee

Abstract

Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.

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Citations

Aug 18, 2016·Frontiers in Immunology·Abigail BassonFabio Cominelli
Oct 21, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Sandra FrugisMariza D D Agostino
Apr 5, 2018·Journal of Zhejiang University. Science. B·Warren ChandaMin-Tao Zhong
Jun 15, 2017·Journal of Medicinal Food·Marina KolundžićTatjana Kundaković
Feb 8, 2020·Nanomedicine·Qianyu ZhangXuefeng Xia
Aug 18, 2016·Helicobacter·Steffen BackertMichael Naumann
Apr 13, 2018·International Journal of Molecular Sciences·Bo Kyeong YoonNam-Joon Cho

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Methods Mentioned

BETA
scanning electron microscopies

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